The e¡ects on slow inactivation (SI) of charge substitutions, neutralizations, and reversals were studied for the negatively charged residues D1309 and EE1314,15 surrounding the IFM motif in the DIII^DIV cytoplasmic linker^the putative fast inactivation particle^of human skeletal muscle voltage-gated sodium channel (hNa V 1.4). Changing aspartate (D) at position 1309 to glutamate (E) (substitution) did not strongly a¡ect SI, whereas charge neutralization to glutamine (Q) and charge reversal to arginine (R) right-shifted the midpoint of the steady-state SI curve. Charge neutralization (DC CQ) at position 1309 also reduced the apparent valence associated with SI. Glutamates (E) at positions 1314 and 1315 were similarly mutated. Charge reversal (EEC CRR) right-shifted the steady-state SI curve and both reversal and substitution (EEC CDD) reduced its apparent valence. Charge neutralization (EEC CQQ) and reversal decreased the maximum probability of SI. These mutations also had di¡erential e¡ects on the rate of SI onset and recovery. These results suggest that charged residues in the DIII^DIV linker may interact with structures that control SI. ß
The Harold B. Lee Library at Brigham Young University (BYU) recently implemented a number of information literacy strategies to help students in Biology 100, a large general education class, find resources for their term assignment. The library's services for Biology 100 students were evaluated using focus groups composed of both teaching assistants and students. This paper will describe the class and the assignment, discuss the impact the class had on library staff, detail the efforts of the staff to meet the needs of Biology 100 students, and present results of focus groups used to evaluate the library's outreach and teaching efforts.
During 2003During -2005, several Brigham Young University (BYU) science librarians conducted a project to upgrade both the print and online journal collections at the Harold B. Lee Library. This systematic approach addressed the collections of several of the departments served by the library's science/maps department, specifically physics, mathematics, chemistry, physiology, developmental biology, and micro/ molecular biology. The methodology involved the creation of separate tables for each subject including subscription cost, annual usage, calculated cost per use, and ISI impact factors. Normalized rankings within each subject were key statistics also given. These tables provided a clear picture that was invaluable in the collaboration with faculty that subsequently occurred in canceling less-used journals and freeing up money for newer (mostly online) subscriptions. Such a systematic approach could also be used in cancellation projects in which no new journals are acquired. Serials Review 2006; 32:4-16. D
The biennial STS continuing education survey was conducted at the end of 200: in collaboration with two other organizations of science librarians. The top continuing education needs of science librarians include new technologies, professional development and keeping current, institutional repositories/digital archives, promoting science information literacy, collaboration between faculty and librarians, and finding free high-quality online data. This paper describes the process of developing and administering the survey and discusses the survey results. [ABSTRACT FROM AUTHOR]
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