The stability of subjective measures of sleep, health, and well-being, as well as the stability of the relationships between sleep and health and well-being were assessed over 3 months. Healthy college students with no consistent sleep complaints completed a 7-day sleep log and battery of surveys related to health and well-being at 3 separate times during the 3 months. Measures of health and well-being were more strongly related to the quality than to the quantity of sleep. Further analyses using the repeated measures results found that participants reported improved sleep and better health, but the affect balance, life satisfaction, and mood states were unchanged across the 3 testing periods. The relationships between the measures of sleep and measures of health and well-being remained constant across the experimental period. Even when working with a non-sleep-disturbed population, healthcare professionals should consider sleep quality as a consistent correlate of daily health and well-being.
The present study was conducted to measure ob mRNA abundance in the zinc-deficient (ZO) rats and the secretion of leptin from adipose tissue obtained from ZO, zinc-adequate (ZA), and pair-fed (PF) rats. It was found that ob mRNA abundance was greatest (P < 0.05) in adipose tissue obtained from ZA and PF rats. Ob mRNA abundance was similar in PF and ZO rats. To study leptin secretion from adipose tissue In a cell culture model, a method was developed to use excised epididymal adipose tissue from ZO, ZA, and PF rats. Tissue was incubated in Opti-modified Eagle's medium (MEM) cell culture medium in which concentrations of zinc and insulin were manipulated. It was observed that leptin secretion was higher (P < 0.05) in adipose tissue obtained from ZA than ZO and PF rats. Secretion of leptin was higher in adipose tissue of PF than ZO rats (P < 0.05). Surprisingly. media zinc content in this ex vivo model tended to suppress secretion of leptin. This suppression seems to be zinc specific and might be caused by the sequestration of insulin in the culture medium. Our results indicate that the reduction in serum leptin observed in ZO rats is likely caused by not only a reduction in body fat, but also by a decrease in leptln synthesis and secretion per gram of adipose tissue. Taking these results into account along with a prior study (1), it is possible that even a marginal zinc deficiency could affect leptin secretion and serum leptin concentrations. Impaired leptin secretion caused by zinc deficiency might be one factor contributing to hypogonadism observed in zinc deficiency.
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