HIV-infected nonimmune adults are at increased risk of severe malaria. This risk is associated with a low CD4+ T cell count. This interaction is of great public health importance.

OBJECTIVES: Vascular access device decision-making for pediatric patients remains a complex, highly variable process. To date, evidence-based criteria to inform these choices do not exist. The objective of the Michigan Appropriateness Guide for Intravenous Catheters in pediatrics (miniMAGIC) was to provide guidance on device selection, device characteristics, and insertion technique for clinicians, balancing and contextualizing evidence with current practice through a multidisciplinary panel of experts.

Serogroup W135 has become endemic in Gauteng, South Africa, causing disease of greater severity than did the previous predominant serogroup A strain.

The polymyxin antibiotic colistin is an antibiotic of last resort for the treatment of extensively drug-resistant Gram-negative bacteria, including carbapenemase-producing Enterobacteriaceae. The State of the World's Antibiotics report in 2015 highlighted South Africa (SA)'s increasing incidence of these 'superbugs' (3.2% of Klebsiella pneumoniae reported from SA were carbapenemase producers), and in doing so, underscored SA's increasing reliance on colistin as a last line of defence. Colistin resistance effectively renders such increasingly common infections untreatable.

The relationships between risk perception and related behavior form a fundamental theme in risk analysis. Despite increasing attentions on the temporal dimension of risk perception and behavior in recent literature, the dynamic relationships between these two constructs remain understudied. Infectious disease outbreaks, such as the Coronavirus Disease 2019 (COVID-19) pandemic, provide a key setting for analyzing evolving perceptions of and responses to natural or human-induced hazards. The main objectives of this research are: (1) to assess temporal changes in cognitive and affective dimensions of perceived COVID-19 risk as well as related protective behavior; and (2) to explore the dynamic relationship between COVID-19 risk perception and behavioral response. Timely data on changing risk perception and behavior related to the COVID-19 outbreak were collected through a series of online surveys from four major cities (Seattle, Los Angeles, Chicago, and New York City; N = 736) and the central Midwest region of the United States ( N = 1240) during March–August 2020. The analysis revealed that: (1) the cognitive and affective dimensions of perceived COVID-19 risk and preventive behavior all changed over time; (2) there were both within- and across-time correlations between COVID-19 risk perception indicators and preventive actions; and (3) preventive actions showed varied feedback effects on individual aspects of perceived COVID-19 risk over time. Findings from this research support and expand major conceptual approaches to changing relationships between risk perception and behavior, particularly the risk reappraisal hypothesis. The study also has useful implications for health risk management and future research directions.

Background:We aimed to describe the epidemiology of candidemia among children in South Africa. Methods: We conducted laboratory-based surveillance among neonates (≤28 days), infants (29 days to <1 year), children (1-11 years) and adolescents (12-17 years) with Candida species cultured from blood during 2012-2017. Identification and antifungal susceptibility of viable isolates were performed at a reference laboratory. We used multivariable logistic regression to determine the association between Candida parapsilosis candidemia and 30-day mortality among neonates. Results: Of 2996 cases, neonates accounted for 49% (n = 1478), infants for 27% (n = 806), children for 20% (n = 589) and adolescents for 4% (n = 123). The incidence risk at tertiary public sector hospitals was 5.3 cases per 1000 pediatric admissions (range 0.39-119.1). Among 2943 cases with single-species infections, C. parapsilosis (42%) and Candida albicans (36%) were most common. Candida auris was among the 5 common species with an overall prevalence of 3% (n = 47). Fluconazole resistance was more common among C. parapsilosis (55% [724/1324]) versus other species (19% [334/1737]) (P < 0.001). Of those with known treatment (n = 1666), 35% received amphotericin B deoxycholate alone, 32% fluconazole alone and 30% amphotericin B deoxycholate with fluconazole. The overall 30-day in-hospital mortality was 38% (n = 586) and was highest among neonates (43% [323/752]) and adolescents (43% [28/65]). Compared with infection with other species, C. parapsilosis infection was associated with a reduced mortality among neonates (adjusted odds ratio 0.41, 95% confidence interval: 0.22-0.75, P = 0.004). Conclusions: Candidemia in this setting mainly affected neonates and infants and was characterized by fluconazole-resistant C. parapsilosis with no increased risk of death.

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In patients requiring extracorporeal membrane oxygenation for cardiac failure, flexible bronchoscopy can be performed safely, provide important diagnostic information to the bedside clinician, and, perhaps, therapeutic benefit to the patient.