Cannabis-derived compounds and therapies targeting the endocannabinoid system (ECS) benefit clinical conditions beyond current indications. As our understanding of the ECS in the skin continues to develop, cannabinoids rapidly show promise for treating cutaneous pathology. However, unstable pharmacokinetics, bioavailability, and skin permeability have been significant constraints on their utility in dermatology. As cannabinoids shift from commercial herbal preparations to prescription drugs, nano-sized drug delivery strategies can tackle these physiochemical limitations and allow welldesigned clinical trials to establish safety and efficacy. This review summarizes the latest evidence for cannabinoids for skin disease, details the challenges of formulating cannabinoids, and highlights how the success of nanomedicine across therapeutic fields can translate to novel nano-cannabinoid therapeutics in dermatology.
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