IN 1951, ORD and THOMPSON described the ability of a number of surface-active agents to 'clear' the opaque supernatants obtained by the centrifugation of water homogenates of whole rat brain. In an attempt to purify the true cholinesterase of brain they further showed that a non-ionic surface-active agent, acetyl alcoholpolyoxyethylene condensate, was able to 'solubilize' this enzyme without causing any inactivation.GROSSE and TAUBOCK (1 942) had earlier briefly reported that a brain brei suspended in physiological saline can be cleared with lysolecithin. A more detailed description
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