This paper proposes a preliminary and large-scale survey methodology to identify areas suitable for indepth analysis for the application of Sustainable Drainage Systems and Managed Aquifer Recharge. These techniques are frequently applied to increase the natural infiltration capacity of water into the ground and their effectiveness depends on the local hydrogeological and morphological characteristics. The study area is the city of Rome where the aim is to mitigate the problems related to rainwater which, in case of extreme events, struggles to infiltrate into the ground, overloads the undersized drainage systems, and floods the urban space.The proposed method involves GIS geospatial analysis of the permeability of outcropping lithologies, the digital elevation model, and the piezometric levels of the aquifers. To identify the suitable zones, areas characterised by high permeability and a piezometric level that would confer a volumetric capacity to possibly store even large quantities of water, without triggering possible problems of water table rise, were identified. Data were divided into classes and indexed to compare and overlap them. Furthermore, the final result was compared with the urban flooding phenomena and the soil permeability map of Rome. The results of the performed analysis show that the preliminary suitable conditions to apply SuDS and MAR in Rome are widespread. The geological setting of the city is characterised by permeable lithologies in many places with an effective infiltration potential that would allow rainwater to infiltrate the subsoil and reach the first available aquifer.
In acute myeloid leukemia (AML) many patients experience relapse, despite the achievement of morphological complete remission; therefore, conventional morphologic criteria are currently considered inadequate for assessing the quality of the response after treatment. Quantification of measurable residual disease (MRD) has been established as a strong prognostic marker in AML and patients that test MRD negative have lower relapse rates and better survival than those who test positive. Different techniques, varying in their sensitivity and applicability to patients, are available for the measurement of MRD and their use as a guide for selecting the most optimal post-remission therapy is an area of active investigation. Although still controversial, MRD prognostic value promises to support drug development serving as a surrogate biomarker, potentially useful for accelerating the regulatory approval of new agents. In this review, we will critically examine the methods used to detect MRD and its potential role as a study endpoint.
<p>This study proposes a survey methodology to identify areas for combined Sustainable Drainage Systems (SUDS) and Aquifer Storage and Recovery (ASR), (Dearden et al. 2013, Sharp Jr., 1997); these techniques exploit the hydrogeological and geomorphological characteristics of an area, to increase the natural capacity of water to infiltrate the ground.</p><p>The target area of this case study is the city of Rome and the aim of such techniques is to reduce the problems related to rainwater which, in case of extreme events, struggles to infiltrate the ground, overloads the undersized hydraulic systems and floods the urban space.</p><p>The proposed method involves GIS geospatial analysis of various data: the permeability of outcropping lithology, the piezometric level of the aquifer, hydrogeological units, geomorphology and land use.</p><p>In this aim zones characterised by high permeability and a piezometric level that would confer a volumetric capacity to possibly store even large quantities of water without triggering possible problems associated with fluctuations in the water table, have been identified.</p><p>The data have been divided into classes and indexed for comparison and overlap them. Finally, hydrogeological units were also taken into account (by analysing their depth trend) in order to identify areas with similar characteristics of permeability with respect to depth. The latter will also be compared with the previous data to identify the areas suitable for SUDS and ASR.</p><p>The final product of the suitable areas from a hydrogeological point of view will be compared with the land use map in order to exclude those areas that, for administrative and other legislative reasons, cannot be used for such activities.</p><p><strong>&#160;</strong></p>
Evolution of myeloproliferative neoplasms (MPN) to acute myeloid leukemia (AML) occurs in 2-10% of patients, whereas the reverse path from AML to MPN has been rarely reported. We herein present a 75-year-old woman with AML, in whom a JAK2-V617F positive polycythemia vera (PV) emerged during follow-up, 19 months from end of consolidation treatment. JAK2-V617F mutation screening retrospectively performed by Next Generation Sequencing (NGS) and JAK2 MutaScreen was negative on the bone marrow sample collected at AML diagnosis. However, using droplet digital PCR (ddPCR), we detected a minor JAK2-V617F mutated clone present at AML onset. A TET2 R550 mutated clone persisted at stable levels throughout the disease course. This case shows that a very small MPN clone masked at AML diagnosis may expand after treatment end, and be erroneously interpreted as MPN evolving from AML. Very sensitive techniques as ddPCR may help to unravel the true disease history in these cases.
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