A case report with progressive weakness, bilateral facial paralysis and acute motor axonal polyneuropathy demonstrating electrodiagnostic evaluation will be presented. The condition was preceded by diarrhea, flu-like infection, abdominal pain and gastric tenderness; eventually, autonomic manifestation with episodes of visual hallucinations and disordered speech was added. Relation with Campylobacter jejuni infection, Lyme disease and porphyria are debated in differential diagnosis. Western-blot tests confirmed Lyme disease, and porphyrin specific test results were found positive.

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Several medicines, especially antimicrobials, play a rolein the etiology of fixed drug eruption (FDE). The clinicalmanifestation is quite typical for a drug-induced reaction.FDE which developed in an 83-year-old male patientwho has been administered colistin due to Acinetobacterpneumonia is presented here since it is very rarely seen.Therefore colistin should also be considered in the differentialdiagnosis of FDE. J Clin Exp Invest 2013; 4 (3):374-376Key words: Fixed drug eruption, etiology, colisti

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ÖzetHashimoto ensefalopatisi, otoimmün etyolojiye bağlı olduğu düşünülen ve yüksek antitiroid antikorları ile birlikte seyreden bir ensefalopati tablosudur. Klinik görünüm global amnezi, psikoz, kognitif etkilenme, epileptik nöbetler şeklinde olabilmektedir. Burada kliniğimize iki yanlı görme bozukluğu, baş ağrısı, davranış değişikliği, uyku düzensizliği şikayeti ile başvuran ve muayenesinde iki yanlı papil ödem saptanıp Pseudotumör serebri (PTS) tanısıyla servisimizde takip edilen 69 yaşında bir kadın hasta sunulacaktır. Etiyolojiye yönelik yapılan tetkiklerinde Hashimato Tiroiditi harici özellik saptanmayan hastaya iki kez yapılan boşaltıcı lomber ponksiyon (LP) ve 5 gün süreyle 1 gr/gün IV metilprednisolon tedavisi uygulanmış ve hastada klinik düzelme gözlenmiştir. PTS tablosuna nadiren Hashimoto ensefalopatisi sebep olması nedeniyle olgumuzu sunmayı uygun gördük. AbstractHashimoto encephalopathy is an encephalopathy associated with high antithyroid antibodies and it is thought to be connected with autoimmune etiology. Clinical presentation may be in the forms of global amnesia, psychosis, cognitive impairment and epileptic seizures. Herein, we will present a case of a 69-year-old female patient who applied to our clinic with bilateral visual impairment, headache, behavioral changes, sleep disorders, bilateral papilledema and established diagnosis of pseudotumor cerebri. As an etiological factor, only Hashimoto thyroiditis was determined. Drainage with lumbar puncture was performed for two times and IV methylprednisolone treatment at daily doses of 1 g was administered for 5 days with resultant clinical improvement. We wanted to present our case of Hashimoto encephalopathy as a rarely seen etiological factor of pseudotumor cerebri.

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Background Ankylosing spondylitis (AS) is a chronic inflammatory disease. AS causes restrictive respiratory disorder by limiting the expansion of the chest. Objectives Our study was planned to evaluate the effect of physiotherapy programme on pulmonary function tests and quality of life in Ankylosing spondylitis patients Methods Fourty AS patients (16 F,24 M) were enrolled in this study. The disease duration, morning stiffness, Schober tests, chest expansion, Erythrocyte Sedimentation Rate (ESR) and C Reactive Protein(CRP) were analyzed and recorded. On the first month of the study, a physiotherapy program was applied in the therapy unite 2 days in every week. A home program including range of motion strenghtening posture and, respiratory exercises 20-30 minutes in every day was prescribed. All the patients received an education and brochure about home exercise programme during the second and the thirth months. The pain was evaluated using visual analog scale (VAS). Disease activity was evaluated by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Pulmonary function tests (FEV1, FEV1/FVC, FVC) were performed with spirometry. Quality of life was evaluated by Health Asssesment Questionnaire Spondyloarthropaties (HAQS). Results The mean disease duration of the patients was 5.83±5.88. Pre and post exercise scores were calculated and compared for each parameter. VAS and BASDAI values significantly decreased after exercises (p=0.012, p=0.020 respectively), while Schober, FEV1 and FEV1/FVC values significantly increased after exercises (p=0.019, p=0.025, p=0.010 respectively). There was an improve in HAQS scores after the physiotherapy programme, however it was not statistically significant. Conclusions Our study showed that physiotherapy programme can be effective for the management of pain, disease activity and respiratory functions. References Karapolat H, Akkoc Y, Sari I, Eyigor S, Akar S, Kirazli Y, Akkoc N,Comparison of group-based exercise versus home-based exercise in patients with ankylosing spondylitis: effects on Bath Ankylosing Spondylitis Indices, quality of life and depression. Clin Rheumatol.2008 Jun;27(6):695-700. Lubrano E, D’Angelo S, Parsons WJ, Corbi G, Ferrara N, Rengo F, Olivieri IEffectiveness of rehabilitation in active ankylosing spondylitis assessed by the ASAS response criteria. Rheumatology (Oxford), 2007 Nov;46(11):1672-5. Analay Y, Ozcan E, Karan A, Diracoglu D, Aydin R. The effectiveness of intensive group exercise on patients with ankylosing spondylitis. Clin Rehabil, 2003 Sep;17(6):631 Fernández-de-Las-Peñas C, Alonso-Blanco C, Alguacil-Diego IM, Miangolarra-Page JCOne-year follow-up of two exercise interventions for the management of patients with ankylosing spondylitis: a randomized controlled trial. Am. J. Phys.Med.Rehabil, 2006 Jul;85(7):559-67. Disclosure of Interest None Declared