Objective: The aim of this study is to describe the main clinical phenotypes, laboratory findings, and severity of coronavirus disease 2019 in patients hospitalized at the High Specialty Medical Unit # 71 of the Mexican Social Security Institute. Methods: Prospective observational cohort study with a total of 105 patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at the High Specialty Medical Unit # 71 (Torreón, Coahuila, Mexico), from May 15th to August 15th, 2020. The cases were confirmed to be COVID-19 positive through an RT-qPCR test. Clinical phenotypes and laboratory tests were evaluated to determine the degree of severity of the disease and the most frequent comorbidities. Results: The clinical characteristics of a total of 105 hospitalized patients (47 females and 58 males; median age being 52 years) with confirmed COVID-19 diagnoses were studied. The severity of the disease was classified as moderate grade (62.7%), severe grade (21.5%), and critical grade (15.6%). Among the most frequent underlying pathologies coexisted overweight (n = 75, 78.12%), obesity (n = 21, 21.87%), diabetes (n = 10, 9.52%), and hypertension (n = 6, 5.71%), some of these patients present more than one pathology. This association was found with diabetes (odds ratio [OR]: 1.42; 95% confidence interval [CI]: 1.23-1.97; p = 0.021) and high levels of D-dimer (OR: 1.01; 95% CI: 1.00-1.08; p = 0.001).
Conclusion:In this retrospective cohort study of patients with COVID-19 from a specialty hospital in the northeast region of Mexico, it was observed that clinical phenotypes and D-dimer elevation were compatible with an inflammatory state by degree of severity; it was found that the hospitalized patients with underlying chronic medical conditions such as diabetes and elevated D-dimer levels were significantly associated with increased mortality from COVID-19. Age and sex (males) were two factors highly associated with mortality.
We present the case of a 65 year old male that was diagnosed with a spontaneous spinal subdural hematoma (SSSH), the initial symptons were back pain and right arm numbness with a latter progression to paraplegia and. The MRI detected an SSSH. Despite the prompt diagnosis and surgical intervention the patient didnt improved has it was spected. This case reveal the fact that despite prompt diagnosis and treatment the morbidity and mortality remains high so it is imperative to have a fresh knowledge of this condition and its clinical manifestations.
We present the case of a 26 year old male that was diagnosed with an acute ascending necrotizing myelitis, the initial symptoms were oppressive pain in the chest and numbness in both hands, followed by weakness of the arms and legs. The MRI detected a hyperintensity from C4 to T1. We suspected a demyelinating event, despite the prompt intervention the patient had progression of the disease, showing an aggressive disease. This case reveals a disease that mimics acute demyelinating diseases.
hipercloremia con mortalidad en pacientes postoperados electivamente de resección de tumores intracraneales Letter to the Editor: Relationship of hyperchloremia with mortality in postoperative patients electively for resection of intracranial tumors Carta ao Editor: Relação da hipercloremia com a mortalidade em pacientes pós-operatórios eletivos de ressecção de tumores intracranianos
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.