Mode 3' allows and emphasises the co-existence and co-evolution of different knowledge and innovation paradigms: the competitiveness and superiority of a knowledge system is highly determined by its adaptive capacity to combine and integrate different knowledge and innovation modes via co-evolution, co-specialisation and co-opetition knowledge stock and flow dynamics. The 'Quadruple Helix' emphasises the importance of also integrating the perspective of the media-based and culture-based public. What results is an emerging fractal knowledge and innovation ecosystem, well-configured for the knowledge economy and society.

The Triple Helix innovation model focuses on university-industry-government relations. The Quadruple Helix embeds the Triple Helix by adding as a fourth helix the 'media-based and culture-based public' and 'civil society'. The Quintuple Helix innovation model is even broader and more comprehensive by contextualizing the Quadruple Helix and by additionally adding the helix (and perspective) of the 'natural environments of society'. The Triple Helix acknowledges explicitly the importance of higher education for innovation. However, in one line of interpretation it could be argued that the Triple Helix places the emphasis on knowledge production and innovation in the economy so it is compatible with the knowledge economy. The Quadruple Helix already encourages the perspective of the knowledge society, and of knowledge democracy for knowledge production and innovation. In a Quadruple Helix understanding, the sustainable development of a knowledge economy requires a coevolution with the knowledge society. The Quintuple Helix stresses the necessary socioecological transition of society and economy in the twenty-first century; therefore, the Quintuple Helix is ecologically sensitive. Within the framework of the Quintuple Helix innovation model, the natural environments of society and the economy also should be seen as drivers for knowledge production and innovation, therefore defining opportunities for the knowledge economy. The European Commission in 2009 identified the socioecological transition as a major challenge for the future roadmap of development. The Quintuple Helix supports here the formation of a win-win situation between ecology, knowledge and innovation, creating synergies between economy, society, and democracy. Global warming represents an area of ecological concern, to which the Quintuple Helix innovation model can be applied with greater potential.

Purpose This study aims to shed light on the internal and external antecedents of open innovation (OI) in the context of small- and medium-sized enterprises (SMEs), with a special focus on the role of knowledge management (KM) capability. The paper develops and tests an integrative research model which assesses the effect of internal factors on KM capability; the impact of organizational and external factors, namely, KM capability and environmental dynamism, on OI; and whether environmental dynamism moderates the relationship between KM capability and OI. Design/methodology/approach Drawing on the knowledge-based view and the social exchange and the contingency theories, this paper develops an integrative research model which analyzes several relations between organizational antecedents of KM capability and its effect on OI by using covariance-based structural equation modeling on a data set of Spanish SMEs. Findings Results confirm that information technology-supported operations and commitment-based human resource practices have a positive and significant influence on KM capability. In contrast, results do not find support for the relationship between interdepartmental connectedness and KM capability, whereas both KM capability and environmental dynamism have a direct influence on OI. Originality/value This paper adds to existing research on OI, as it is the first study that addresses the critical role of KM capability for the implementation of OI.

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Regions are increasingly being viewed as eco-systemic agglomerations of organizational and institutional entities or stakeholders with socio-technical, socio-economic, and sociopolitical conflicting as well as converging (co-opetitive) goals, priorities, expectations, and behaviors that they pursue via entrepreneurial development, exploration, exploitation, and deployment actions, reactions and interactions. In this context, our paper aims to explore and profile the nature and dynamics of the Quadruple/Quintuple Helix Innovation System Model or Framework (government, university, industry, civil society, environment) as an enabler and enactor of regional co-opetitive entrepreneurial ecosystems which we conceptualize as fractal, multi-level, multi-modal, multi-nodal, and multi-lateral configurations of dynamic tangible and intangible assets within the resource-based view and the new theory of the growth of the firm. Co-opetitive fractal innovation and entrepreneurship ecosystems are defined and discussed, and examples of regional innovation 148 V C 2017 RADMA and John Wiley & Sons Ltd policies and programs are presented. Furthermore, the concept of multi-level innovation systems is analyzed, taking into account the existence of knowledge clusters and innovation networks, while alternative aggregations of multi-level innovation systems are proposed based on their spatial (geographical) and non-spatial (research-based) functional properties.

This article develops an inter-disciplinary and trans-disciplinary framework of analysis that relates knowledge, innovation and the environment (natural environments) to each other. For that purpose the five-helix structure model of the Quintuple Helix is being introduced. The Triple Helix model, designed by Etzkowitz and Leydesdorff (2000), focuses on the relations of universities, industry and governments. The Quadruple Helix (Carayannis & Campbell, 2009) blends in the perspective of a media-based and culture-based public. The Quintuple Helix finally frames knowledge and innovation in the context of the environment (natural environments). Therefore, the Quintuple Helix can be interpreted as an approach in line with sustainable development and social ecology. “Eco-innovation” and “eco-entrepreneurship” should be processed in such a broader understanding of knowledge and innovation.

The combination of knowledge and innovation has become a cornerstone among knowledge and labour intensive enterprises. A growing number of enterprises are defined as knowledge intensive entrepreneurship ventures that have been widely studied in relation to their ecosystem. However only few research have addressed this phenomenon to enterprises digital ecosystem by adopting mainly a qualitatively approach. We point out that the relevance of the digital ecosystem focusing on the role of social networking sites in relationship to innovation and knowledge. The use of social networking sites can provide a wealth of information about individuals and their networks, which can be utilised for various business purposes. It enables enterprises to create online communities and share user-created content. Within this context, enterprises actively interact with external actors such as customers, public institutions, and other businesses to acquire and absorb external knowledge, and then generate innovation. To gain insights from the global economy, 215 small to medium enterprises from different sets of global enterprises, both knowledgeintensive (e.g. management consulting, marketing and advertising, ICT and related services, legal and technical services) and labour-intensive (such as high tech and electronics, food and beverage, and consumer durables), were analysed. Via the Partial Least Square-Path Modelling the relationships between social networking sites, absorptive capacity, and innovation performance were measured. Therefore, recommendations are proffered as to what small-medium enterprises should do in order to enhance their innovativeness. The research ends with conclusions and implications to both scholars and practitioners.

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