Objective: Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and social interaction and by restricted and repetitive patterns of behavior. Some studies have shown that substances derived from Cannabis sativa improve the quality of life of children with ASD without causing serious adverse effects, thus providing an alternative therapeutic option. The objective of this study was to evaluate the efficacy and safety of a cannabis extract rich in cannabidiol (CBD) in children with ASD. Methods: In this randomized, double-blind, placebo-controlled clinical trial, 60 children, aged from 5 to 11 years, were selected and divided into two groups: the treatment group, which received the CBD-rich cannabis extract, and the control group, which received the placebo. They both used their respective products for a period of 12 weeks. Statistical analysis was done by two-factor mixed analysis of variance (two-way ANOVA). Results: Significant results were found for social interaction (F 1,116 = 14.13, p = 0.0002), anxiety (F 1,116 = 5.99, p = 0.016), psychomotor agitation (F 1,116 = 9.22, p = 0.003), number of meals a day (F 1,116 = 4.11, p = 0.04), and concentration (F 1,48 = 6.75, p = 0.01), the last of which was only significant in mild ASD cases. Regarding safety, it was found that only three children in the treatment group (9.7%) had adverse effects, namely dizziness, insomnia, colic, and weight gain. Conclusion: CBD-rich cannabis extract was found to improve one of the diagnostic criteria for ASD (social interaction), as well as features that often co-exist with ASD, and to have few serious adverse effects.

RESUMO: O objetivo do estudo foi investigar as condições de vida de adolescentes do sexo feminino em situação de rua, envolvidas com o abuso de drogas e com a prostituição, visando orientar estratégias de prevenção às doenças Sexualmente transmissíveis -dSt/aIdS. Foram entrevistadas sete adolescentes entre 14 e 19 anos, por meio de roteiro semi-estruturado com questões sobre escolaridade; desligamento da família; violência; histórico de uso de drogas, sexualidade e existência de dSt/aIdS; vida na rua e futuro. Observou-se que os principais motivos que levaram essas adolescentes à rua foram violência doméstica; baixo nível sócio-econômico familiar e abuso de múltiplas drogas. As entrevistadas afirmaram conhecer medidas preventivas para as DST/AIDS, porém não as aplicaram aos clientes fixos e namorados. A análise dos resultados obtidos nesta pesquisa confirma a importância da criação de estratégias específicas para as DST/AIDS, além da adequação da rede educacional e de atenção psicossocial às necessidades das adolescentes para a garantia de seus direitos e conquista da emancipação.PALAVRAS-CHAVE: adolescência; violência doméstica; abuso de drogas; prostituição; aIdS. StREEt YOUtH: PROStItUtION, dRUGS aNd HIV/aIdS IN SaNtO aNdRÉ-BRaZIlABSTRACT: the aim of this study was to investigate living conditions of female street adolescents, who are involved with illicit and licit drugs, and with prostitution, in the city of Santo andré, as well as to tailor strategies for Std/aIdS prevention. We have interviewed seven adolescents, aged from 14 to 19 years old, using a semi-structured questionnaire with questions about education, family disaffection, violence, living on the streets, history of drug use, sexuality, level of information about Std/aIdS, and hopes for the future. We observed that among the reasons for these adolescents to live on the streets were domestic violence, low socioeconomic level, and drug abuse. they stated that they are aware of Std/aIdS preventive measures, but they do not bring them into effect with steady partners and boyfriends. The analysis of our results confirms the importance of creating well-defined strategies to STD/AIDS prevention, additionally to suitable educational system and psychosocial attention service. this will assure adolescents' rights and emancipation.

This qualitative study investigated the vulnerability to HIV/AIDS among adolescents who live on the streets, and are involved in prostitution, drugs and violence, in Santo André City (Brazil). Methods: from december 2003 to january 2004, seven respondents were recruited using youth key informants. Data were collected through semi-structured interviews. Blood was drawn to determine syphilis, hepatitis B, hepatitis C and HIV status: Results: Six youths were positive for syphilis, one was HIV positive and one was HIV undetermined. The findings highlighted that history of domestic violence, rape, curiosity to life on street, assertion of sexuality, drug abuse teses

Descritores: 1.Adolescente 2.Mulheres 3.Prostituição/psicologia 4.Doenças sexualmente transmissíveis/psicologia 5.HIV 6.Transtornos relacionados ao uso de substâncias/psicologia 7.Psicanálise 8.Gravidez na adolescência USP/FM/SBD-195/08 Normalização adotadaEsta apresentação está de acordo com:Referências: adaptadas do International Committee of Medical Journals Editors (Vancouver).

O objetivo deste estudo foi caracterizar morfométricamente folíolos de mudas de M. oleifera por método destrutivo. A pesquisa foi realizada no Centro de Ciências Agrárias e Ambientais da Universidade Estadual da Paraíba. Foram coletados 200 folíolos de M. oleifera, nos quais foram realizadas medidas para determinação do comprimento (C) e da largura (L) e, posteriormente, a área foliar foi determinada utilizando-se do softwareImageJ®. Verificou-se que folíolos de M. oleifera possuem comprimento médio de 1,595±0,474 cm, com valores variando de 0,695 cm a 2,831 cm, largura média dos folíolos de 1,142±0,329 cm, variando de 0,443 a 1,950 cm e área média de 1,445±0,800 cm2, com valores variando entre 0,253 cm2 e 3,602 cm2. Trabalhos complementares são sugeridos para criação de modelos lineares para determinação da área dos folíolos por métodos não destrutivos.