Background
Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide.
Methods
By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARS-CoV-2 introductions and early dissemination in Portugal.
Results
We detected at least 277 independent SARS-CoV-2 introductions, mostly from European countries (namely the United Kingdom, Spain, France, Italy, and Switzerland), which were consistent with the countries with the highest connectivity with Portugal. Although most introductions were estimated to have occurred during early March 2020, it is likely that SARS-CoV-2 was silently circulating in Portugal throughout February, before the first cases were confirmed.
Conclusions
Here we conclude that the earlier implementation of measures could have minimized the number of introductions and subsequent virus expansion in Portugal. This study lays the foundation for genomic epidemiology of SARS-CoV-2 in Portugal, and highlights the need for systematic and geographically-representative genomic surveillance.
ResumoO teste de caminhada de seis minutos -TC6'-é amplamente utilizado para avaliação da capacidade física e do prognóstico de diversas doenças, em que a distância percorrida no TC6' (DTC6') é uma das principais variáveis para interpretá-lo. Vários estudos desenvolveram equações para obter a distância predita no TC6' -DPTC6', porém as equações de predição mais conhecidas na literatura foram desenvolvidas com indivíduos saudáveis. O objetivo deste estudo foi analisar e correlacionar a DTC6'com a DPTC6' por meio das equações de Enright et al.
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