The extraction of Flavonoids from dried ginger ( Zingiber officinale Ros.) roots in addition of non-flavonoids parts (oils and defatted) were studied against H 2 O 2 induced oxidative stress in the serum of male rats for 15 day.Fifty male rats with age of 3-4 months and weight of 225-300 g were divided into 5 groups : group (1): control group received drinking tab water and ideal diet, group (2): received 0.5% H 2 O 2 in drinking tab water , group (3): received 0.5% H 2 O 2 and oral dose of 15 mg/ kg of BW. flavonoids once daily, group (4): received 0.5% H 2 O 2 and oral dose of 30 mg/ kg BW flavonoids once daily. Group (5): received 0.5% H 2 O 2 and the experimental diet ( 50 g non-flavonoids part / kg diet).H 2 O 2 treated group showed elevation in serum cholesterol, malondialdehyde (MDA), peroxynitrite radical levels and reduction in glutathione (GSH), vit C, albumin, calcium, and phosphorus levels compared with the control group (p≤ 0.05). Treatment with ginger extracts counteracted the oxidative stress induced by H 2 O 2 by reducing the levels of cholesterol, MDA and peroxynitrite and enhancing the levels of GSH, vit C, albumin and calcium compared with the H 2 O 2 treated group (p≤ 0.05). Treatment with non flavonoids part, by means of experimental diet, showed decreasing in the MDA, peroxynitrite, phosphate levels and increasing in vit C level compared with the H 2 O 2 treated group (p≤ 0.05). The results of the present study provided the protective effects of the ginger extract by increasing antioxidant defense and suppression free radicals production in the serum.
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