Background/objective: Published studies have shown conflicting results regarding the rate of wound infection between primary and delayed closures in open appendicectomy. This meta-analysis was performed with the aim to summarize all available evidence. Methods: A literature search was carried out using Medline, PubMed, EMBASE and Cochrane databases from inception to January 2018. Randomized controlled studies that compared primary closure (PC) to delayed closure (DC) in appendicectomy were included. Pooled odds ratio and 95% confidence interval were calculated using Mantel-Haenszel fixed-effects model when there was no heterogeneity identified. Results: Of the 471 retrieved studies, eight met the eligibility criteria and were included in the analysis. These trials included 1,263 patients, of whom 623 patients underwent delayed closure and 640 primary closure. Surgical Site Infections SSI rates were not significantly different between the DC and PC groups (16.25% & 12.68% respectively. OR=0.60, 95% CI: 0.23-1.54. There was a high heterogeneity among the analyzed studies (I2=82%). Conclusion: This meta-analysis found no benefit in performing delayed primary closure over primary closure in open appendicectomy. Highlights:
Background & aim Bibliometric analysis is used to explore the historical development in a particular field. The aim is to identify and analyse most cited papers in benign anorectal disease in the last 7 decades (1950–2018). Method Thomson Reuters Web of Science database was used to find the top 100 cited articles in benign anorectal conditions. Papers were independently extracted by two investigators. The top 100 cited articles were identified and ranked according to number of citations. The articles were then sorted by author, journal, institution, country and publication date. The study subject was divided into 5 groups. Results The most frequently cited article received 1307 citations whereas the least cited received 154 citations. The earliest recorded article was published in 1960 and the most recent was from 2010. More than half of the articles addressed faecal incontinence and sphincter related literature (n = 54). The articles were published in 29 different journals. A majority (69%) of manuscripts originated from the USA (n = 35; 9221 citations) and UK (n = 34; 7796 citations). The origin of these top 100 classic papers was from 53 different institutions. St. Mark's Hospital in the UK had the highest number of articles (n = 21), followed by Cleveland clinic (n = 5) and University of Minnesota (n = 5). Conclusion The most highly cited manuscripts in benign anorectal disease cover a wide range of topics. Faecal incontinence and sphincter related articles had the highest number of citations. This review serves as a reference for researchers to find the influential papers in this field.
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