Exposure to ultraviolet B (UVB) has an impact in the form of changes in the dermis collagen fibers and can result in decreasing the thickness and density of collagen. This study aims to assess the effectiveness of mangosteen pericarp extract to the thickness and density of collagen in mice skin after being exposed to UVB. This research was conducted in the animal laboratory and the anatomic pathology laboratory Hasanuddin University, Makassar. The study used pure animal experimental research design with control group. The samples were 24 mice that were divided into four groups: normal, UVB, ethanol and mangosteen groups. Mangosteen pericarp extract with a concentration of 50% was applied shortly after the mice were exposed to UVB. The thickness and density of collagen in normal group was significantly higher than UVB and ethanol groups. Mangosteen groups showed collagen density higher than UVB and ethanol groups. No significant differences between mangosteen and normal group. No significant differences between ethanol and UVB groups. Mangosteen pericarp extract with a concentration of 50% (2 mg / gBW mice) can increase the thickness and density of collagen in mice skin exposed to UVB.
Remaja putri merupakan bagian dari populasi yang sangat mudah terpengaruh dalam menggunakan krim pemutih wajah dikarenakan pada masa remaja terbentuk perasaan baru mengenai identitas diri dan mulai cemas terhadap penampilan fisik. Diperlukannya pengetahuan yang baik dalam menggunakan krim pemutih wajah sebab masih banyak ditemukan krim pemutih wajah yang mengandung zat berbahaya seperti salah satunya yaitu hidrokuinon. Tujuan dari peneilitian ini adalah untuk mendeskripsikan tingkat pengetahuan remaja putri tentang bahaya hidrokuinon pada krim pemutih wajah. Penelitian ini adalah penelitian deskriptif dengan memakai desain cross sectional, dilaksanakan pada bulan Maret 2021. Populasi penelitian ini adalah seluruh siswi SMAS Sukma Bangsa Pidie, dengan total sampel sebanyak 71 orang yang diambil secara total sampling. Pengumpulan data dijalankan dengan cara pengisian kuesioner melalui google form. Analisa dalam penelitian ini menggunakan analisa univariat menggunakan program komputer. Dari hasil penelitian didapatkan pengetahuan baik sebanyak 37 responden (52,1%). Responden yang memiliki pengetahuan baik mengenai bahaya hidrokuinon pada krim pemutih wajah paling banyak berumur 16 tahun (66,7%) dan paling banyak berada pada kelas XI sebanyak 13 responden (68,4%) dan kelas XII sebanyak 13 responden (44,8%). Berlandaskan hasil penelitian bisa disimpulkan jika pengetahuan remaja putri di SMAS Sukma Bangsa Pidie berada dalam kategori baik. Kata Kunci: Pengetahuan, Krim Pemutih, Hidrokuinon.
Exposure to ultraviolet B (UVB) can have an impact on the epidermis and dermis that triggers inflammatory processes that affect angiogenesis in the skin. Our study aimed to assess the effectiveness of mangosteen pericarp extract against angiogenesis in mouse skin after being exposed to UVB. This research was carried out with animals in the anatomic pathology laboratory of Hasanuddin University in Makassar. We used an animal experimental research design with a control group. A total of 24 mice were divided into the following 4 sample groups: normal group, UVB group, ethanol group and mangosteen group. In the mangosteen group, mangosteen pericarp extract with a concentration of 50% was smeared on the mice shortly after they were exposed to UVB. The amount of vascularization was significantly different among the groups. The greatest amount of vascularization was found in the ethanol group and the least amount was found in the normal group. The amount of vascularization in the mangosteen group was significantly lower than the UVB and ethanol groups but significantly higher than the normal group. In conclusion, the mangosteen pericarp extract concentration of 50% (2 mg/g of mouse weight) reduced the amount of angiogenesis, which is a marker of inflammation, in the skin of the mice that were exposed to UVB.
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