Silicon glycerolates of the general formula Si(C 3 H 7 O 3 ) 4 × xC 3 H 8 O 3 (3 £ x £ 10) and related hydrogels of the general formula Si(C 3 H 7 O 3 ) 4 × xC 3 H 8 O 3 × yH 2 O (3 £ x £ 10, 20 £ y £ 40) were synthesized and some of their pharmacological properties were studied. The laws of gel formation were investigated and optimum conditions for the process were determined. High percutaneous (transdermal) activity of the synthesized compounds was revealed by measuring the diffusion of drugs through intact skin membrane in vitro. The acute and chronic toxicity was studied. It was established that all substances are nontoxic. The experimental results show that silicon glycerolates and related hydrogels can be recommended for further testing and investigation as effective biologically active percutaneous vehicles of medicinal preparations.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.