The title complex ( tBuPCP)IrH(Cl) (1; tBuPCP = κ3-2,6-(CH2PtBu2)2C6H3) appeared to be moderately active in NHMe2·BH3 (DMAB) dehydrogenation, allowing the systematic spectroscopic (variable-temperature NMR and IR) investigation of the reaction intermediates and products, under both stoichiometric and catalytic regimes, combined with DFT/M06 calculations. The formation of the hexacoordinate complex (tBuPCP)IrHCl(η1-BH3·NHMe2) (3) stabilized by a NH···Cl hydrogen bond is shown experimentally at the first reaction step. This activates both B–H and Ir–Cl bonds, initiating the precatalyst activation and very first DMAB dehydrogenation cycle. The same geometry is suggested by the DFT calculations for the key intermediate of the catalytic cycle, (tBuPCP)IrH2(η1-BH3·NHMe2) complex (6). In these complexes, DMAB is coordinated trans to the ipso carbon, allowing the steric repulsion between the amine–borane and tert-butyl groups at the phosphorus atoms to be overcome. Under catalytic conditions (2–5 mol % of 1) the hydride complex (tBuPCP)IrH(μ2-H2BH2) (5) was identified, which is not a dormant catalytic species but the steady-state intermediate formed as a result of the B–N bond breaking. DMAB dehydrogenation yields the borazane monomer H2BNMe2 (detected by 11B NMR); dimerization of this species gives the final product [H2BNMe2]2 and (tBuPCP)IrH4 as the catalyst resting state. The scenario of B–N bond cleavage in DMAB leading to byproducts of dehydrogenation such as bis(dimethylamino)hydroborane and (tBuPCP)IrH(μ2-H2BH2) (5) is proposed. The results obtained allow us to suggest the mechanism of catalytic DMAB dehydrocoupling that could be generalized to other processes.
The Ir III hydride ( tBu PCN)IrHCl (1) containing the tridendate unsymmetrical pincer ligand tBu PCN − { tBu PCN(H) = 1-[3-[(ditert-butylphosphino)methyl]phenyl]-1H-pyrazole} has been exploited as ammonia borane (NH 3 BH 3 , AB) and amine boranes dehydrogenation catalyst in THF solution at ambient temperature. 1 releases one H 2 equivalent per AB equivalent, with concomitant cyclic poly(aminoboranes) formation [B-(cyclotriborazanyl)-amine-borane (BCTB) and cyclotriborazane (CTB)] as the final "spent fuel". 1 has been found to have superior catalytic activity than its symmetrical analogue ( tBu PCP)IrHCl, with recorded TOF values of 580 h −1 (AB in THF) and 401 h −1 (DMAB in toluene) at ambient temperature. The reaction has been analyzed experimentally through multinuclear [ 11 B, 31 P{ 1 H}, 1 H] NMR and IR spectroscopy, kinetic rate measurements, and kinetic isotope effect determination with deuterated AB isotopologues. The hydride/borohydride intermediate ( tBu PCN)IrH(η 2 -BH 4 ) (2) is the catalyst resting state formed during the dehydrogenation process; it is detected by a variable-temperature multinuclear NMR of the reaction course (in the 190−323 K range). A DFT modeling of the reaction mechanism using DMAB as substrate has been performed with the geometry optimization in toluene at the M06 level of theory. The combination of the kinetic and computational data reveals that a simultaneous B−H/N−H activation occurs in the presence of 1, after the preliminary amine borane coordination to the metal center.
54Заболеваемость и смертность от сердечно-сосудис тых заболеваний (ССЗ) занимает первое место во многих странах мира, в том числе и в России [1]. Поэтому профилактика ССЗ, особенно в группах высокого риска, является приоритетным направле-нием современной кардиологии.Одна из таких групп высокого риска -пациенты с ожирением. Женщины, как правило, имеют более высокую степень ожирения на протяжении всей жизни, этот фактор риска (ФР) у женщин имеет боль-шое социальное значение, так как связан с наруше-нием репродуктивного здоровья, осложнением тече-ния беременности и возможной неонатальной забо-леваемостью [2,3]. Ряд исследований свидетельствуют о высокой встречаемости субклинического атеро-склероза магистральных артерий среди бессимптом- Шенкова Н. Н. -врач-кардиолог, Веселовская Н. Г. -д. м.н., зав. кардиологи-ческим отделением № 4, Алтайского краевого кардиологического диспансера, с. н.с. отдела мультифокального атеросклероза, Чумакова Г. А.* -д. м.н., про-фессор кафедры терапии и общей врачебной практики ФПК и ППС, в. н.с. отдела мультифокального атеросклероза, Осипова Е. С. -спирант кафедры терапии и общей врачебной практики ФПК и ППС, Гриценко О. В. -к. м.н., врач-кардиолог, Отт А. В. -врач-кардиолог Алтайского краевого кардиологи-ческого диспансера. ПРОГНОЗИРОВАНИЕ РИСКА СУБКЛИНИЧЕСКОГО АТЕРОСКЛЕРОЗА БРАХИОЦЕФАЛЬНЫХ АРТЕРИЙ У ЖЕНЩИН С ОЖИРЕНИЕМ*Автор, ответственный за переписку (Corresponding author): g. a.chumakova@mail.ru ССЗ -сердечно-сосудистые заболевания, ФР -факторы риска, ИБС -ише-мическая болезнь сердца, ЭЖТ -эпикардиальная жировая ткань, ВЖТ -вис-церальная жировая ткань, БЦА -брахиоцефальные артерии, СД -сахарный диабет, ИМТ -индекс массы тела, ТКИМ -толщина комплекса интима медиа, АБ -атеросклеротическая бляшка, САД -систолическое артериальное дав-ление, ОИМ -острый инфаркт миокарда, тЭЖТ -толщина эпикардиальной жировой ткани, ВО -висцеральное ожирение. Aim. To reveal the complex of metabolic risk factors, most significantly related to subclinical atherosclerosis of brachiocephalic arteries (BCA) in obese women. Material and methods. Totally, 89 women included, at the age 25-59 y. o. (50,6±6,6 y. o.) with abdominal obesity -waist circumference >80 cm with no clinical signs of coronary heart disease and atherosclerosis of other localizations. All women underwent duplex DCA scanning with the intima-media thickness assessment (IMT). Also, the main metabolic risk factors were assessed, adipokines of visceral fat tissue, ghrelin. Epicardial fat thickness (tEFT) in millimeters was measured by echo. Veloergometry was performed, to rule out angina and silent myocardial ischemia; cardiovascular risk assessment by SCORE, Framingham, PROCAM. Results. In 32,6% women there were signs of BCA atherosclerosis (IMT more than 1,3-1,5 mm). An equation was invented for logistic regression with the most significant predictors group (ghrelin, CRP, tEFT, leptin), related to subclinical BCA atherosclerosis in obese women, with sensitivity 89,7%. Conclusion. The complex of RF that were collected, might be used in clinical p...
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