The PedsQL 3.2 Diabetes Module Diabetes Symptoms and Diabetes Management Summary Scores demonstrated excellent measurement properties and may be useful as standardized patient-reported outcomes of diabetes symptoms and diabetes management in clinical research, clinical trials, and practice in children, adolescents, and young adults with type 1 diabetes.

Diabetes management explains in part the effects of diabetes symptoms on HRQOL in AYA with type 1 diabetes. Patient health communication to healthcare providers and perceived treatment adherence barriers further explain the mechanism in the relationship between diabetes symptoms and overall HRQOL.

Aim To test the measurement properties of the revised and updated Pediatric Quality of Life Inventory (PedsQL) 3.2 Diabetes Module originally developed in Type 1 diabetes in youth with Type 2 diabetes. Methods The PedsQL 3.2 Diabetes Module and PedsQL Generic Core Scales were administered in a field test study to 100 young people aged 9–25 years with Type 2 diabetes. Factor analysis was conducted to determine the factor structure of the items. Results The 15‐item Diabetes Symptoms Summary Score and 12‐item Type 2‐specific Diabetes Management Summary Score were empirically derived through factor analysis. The Diabetes Symptoms and Type 2‐specific Diabetes Management Summary Scores showed acceptable to excellent reliability across the age groups tested (α = 0.85–0.94). The Diabetes Symptoms and Type 2‐specific Diabetes Management Summary Scores evidenced construct validity through large effect size correlations with the Generic Core Scales Total Scale Score (r = 0.67 and 0.57, respectively). HbA1c was correlated with the Diabetes Symptoms and Type 2‐specific Diabetes Management Summary Scores (r = −0.13 and −0.22). Minimal clinically important difference (MCID) scores were 5.91 and 7.39 for the Diabetes Symptoms and Type 2‐specific Diabetes Management Summary Scores. Conclusions The PedsQL 3.2 Diabetes Module Diabetes Symptoms Summary Score and Type 2‐specific Diabetes Management Summary Score exhibited satisfactory measurement properties for use as youth self‐reported diabetes symptoms and diabetes management outcomes for clinical research and clinical practice for young people with Type 2 diabetes.

Diabetes symptoms are potentially modifiable predictors of generic HRQOL in AYA with diabetes. Identifying specific diabetes symptoms or symptoms facets that are the most important predictors from the patient perspective facilitates a patient-centered approach in clinical research, clinical trials, and practice designed to enhance overall generic HRQOL in AYA with diabetes.