Diabetes management mediating effects between diabetes symptoms and health-related quality of life in adolescents and young adults with type 1 diabetes

Varni, James W.; Delamater, Alan M.; Hood, Korey K.; Driscoll, Kimberly A.; Wong, Jenise C.; Adi, Saleh; Yi‐Frazier, Joyce P.; Grishman, Ellen K.; Faith, Melissa A.; Corathers, Sarah; Kichler, Jessica C.; Miller, Jennifer; Raymond, Jennifer; Doskey, Elena M.; Aguirre, Vincent; Heffer, Robert W.; Wilson, Don P.

doi:10.1111/pedi.12713

Cited by 22 publications

(22 citation statements)

References 40 publications

(80 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A revised and updated measure of diabetes‐specific quality of life has recently been shown to be reliable and valid for use in pediatric and adolescent patients with T1D, providing scores for diabetes symptoms and diabetes management . Research has shown that diabetes symptoms are associated with general health‐related quality of life, which is partially mediated by diabetes management …”

Section: Quality Of Lifementioning

confidence: 99%

See 1 more Smart Citation

ISPAD Clinical Practice Consensus Guidelines 2018: Psychological care of children and adolescents with type 1 diabetes

et al. 2018

View full text Add to dashboard Cite

Section: Quality Of Lifementioning

confidence: 99%

“…172 Research has shown that diabetes symptoms are associated with general health-related quality of life, which is partially mediated by diabetes management. 173…”

Section: Quality Of Lifementioning

confidence: 99%

ISPAD Clinical Practice Consensus Guidelines 2018: Psychological care of children and adolescents with type 1 diabetes

et al. 2018

View full text Add to dashboard Cite

“…To address this significant gap in the SCD empirical literature, we include perceived cognitive functioning difficulties as a mediator variable in a multiple mediator conceptual model that builds on similar conceptual models tested in youth with inflammatory bowel disease, type 1 diabetes, and neurofibromatosis type 1 16‐19 . Specifically, our prior research demonstrated that patient health communication was a mediating variable in the relationship between symptoms and disease‐specific worry in youth with inflammatory bowel disease, 16 and subsequently total generic HRQOL 17 .…”

Section: Introductionmentioning

confidence: 99%

Cognitive functioning, patient health communication, and worry mediate pain predictive effects on health‐related quality of life in youth with sickle cell disease

Varni¹

2020

Pediatric Blood & Cancer

Self Cite

View full text Add to dashboard Cite

Objectives: The objective was to investigate the serial mediating effects of perceived cognitive functioning, patient health communication, and disease-specific worry in the relationship between pain and overall generic health-related quality of life (HRQOL) in youth with sickle cell disease (SCD) from the patient perspective. Methods: The pain, cognitive functioning, communication and worry scales from the Pediatric Quality of Life Inventory (PedsQL) Sickle Cell Disease Module and the Ped-sQL Multidimensional Fatigue Scale, and the PedsQL 4.0 Generic Core Scales were completed in a multisite national study by 233 youth with SCD of ages 5-18. Hierarchical multiple regression and serial multiple mediator model analyses were conducted to test the mediating effects of perceived cognitive functioning, health communication, and disease-specific worry as intervening variables in the association between the pain predictor variable and overall generic HRQOL. Results: Pain predictive effects on overall generic HRQOL were serially mediated by cognitive functioning, health communication, and disease-specific worry. In predictive analytics models utilizing hierarchical multiple regression analyses with age and gender demographic covariates, pain, cognitive functioning, health communication, and worry accounted for 65% of the variance in patient-reported overall generic HRQOL (P < .001), representing a large effect size. Conclusions: Perceived cognitive functioning, patient health communication, and disease-specific worry explain in part the mechanism of pain predictive effects on overall generic HRQOL in youth with SCD. Identifying SCD-specific pain, perceived cognitive functioning, health communication, and disease-specific worry as predictor variables of overall generic HRQOL from the patient perspective may inform clinical interventions and future patient-centered clinical research.

show abstract

“…To address this significant gap in the NF1 empirical literature, we included speech difficulties as a mediator variable in a serial multiple mediator conceptual model that builds on conceptual models tested in pediatric inflammatory disease and Pediatric Type 1 Diabetes (Varni, Delamater, et al, ; Varni et al, ; Varni, Shulman, et al, ). Specifically, our prior research demonstrated that patient health communication was a mediating variable in the relationship between symptoms and disease‐specific worry in pediatric patients with inflammatory bowel disease (Varni et al, ), and subsequently total generic HRQOL (Varni, Shulman, et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Specifically, our prior research demonstrated that patient health communication was a mediating variable in the relationship between symptoms and disease‐specific worry in pediatric patients with inflammatory bowel disease (Varni et al, ), and subsequently total generic HRQOL (Varni, Shulman, et al, ). This conceptual model of patient health communication as a mediating variable between disease‐specific symptoms and total generic HRQOL was also tested and supported in Pediatric Type 1 Diabetes (Varni, Delamater, et al, ). Patient–clinician health communication is important to measure since it may facilitate patient decision‐making concerning the advantages and disadvantages of different treatment options in managing disease‐specific symptoms, while supportive communication from healthcare providers may directly address patient disease‐related worry (Fogarty, Curbow, Wingard, McDonnell, & Somerfield, ), and subsequently positively impact overall HRQOL.…”

Section: Introductionmentioning

confidence: 99%

Speech difficulties and patient health communication mediating effects on worry and health‐related quality of life in children, adolescents, and young adults with Neurofibromatosis Type 1

Varni

Nutakki

Swigonski

2019

American J of Med Genetics Pt A

Self Cite

View full text Add to dashboard Cite

The objective was to investigate the serial mediating effects of speech difficulties, patient health communication, and disease-specific worry in the relationship between neurofibromatosis (NF) symptoms (pain and skin symptoms) and total generic healthrelated quality of life (HRQOL) in children, adolescents, and young adults with NF Type 1 (NF1) from the patient perspective. The Speech, Communication, Worry, Pain, Skin Itch Bother, and Skin Sensations Scales from the Pediatric Quality of Life Inventory (PedsQL) NF1 Module and the PedsQL 4.0 Generic Core Scales were completed in a multi-site national study by 305 patients ages 5-25 years. A serial multiple mediator model analysis was conducted to test the hypothesized sequential mediating effects of speech difficulties, health communication, and worry as intervening variables in the association between NF1 symptoms and HRQOL. Symptoms predictive effects on total generic HRQOL were serially mediated by speech difficulties, patient health communication, and worry. In predictive analytics models utilizing hierarchical multiple regression analyses with age and gender demographic covariates, the pain, skin itch bother, and skin sensations multiple mediator models accounted for 61%, 59%, and 56% of the variance in generic HRQOL (p < .001), reflecting large effect sizes. Speech difficulties, patient health communication, and disease-specific worry explain in part the mechanism of symptoms predictive effects on total generic HRQOL in pediatric patients with NF1. Identifying NF1-specific predictors and serial mediators of total generic HRQOL in pediatric patients with NF1 from the patient perspective enables a patient-centered comprehensive care approach for children, adolescents, and young adults with NF1. K E Y W O R D S communication, health-related quality of life, neurofibromatosis, patient-reported outcomes, PedsQL, speech Abbreviations: HRQOL, health-related quality of life; NF1, Neurofibromatosis Type 1; PedsQL, Pediatric Quality of Life Inventory.The PedsQL is available at http://www.pedsql.org.

show abstract

Diabetes management mediating effects between diabetes symptoms and health-related quality of life in adolescents and young adults with type 1 diabetes

Cited by 22 publications

References 40 publications

ISPAD Clinical Practice Consensus Guidelines 2018: Psychological care of children and adolescents with type 1 diabetes

ISPAD Clinical Practice Consensus Guidelines 2018: Psychological care of children and adolescents with type 1 diabetes

Cognitive functioning, patient health communication, and worry mediate pain predictive effects on health‐related quality of life in youth with sickle cell disease

Speech difficulties and patient health communication mediating effects on worry and health‐related quality of life in children, adolescents, and young adults with Neurofibromatosis Type 1

Contact Info

Product

Resources

About