The purpose of this paper is to evaluate the feasibility of diagnosing multiple sclerosis (MS) using optical coherence tomography (OCT) data and a support vector machine (SVM) as an automatic classifier. Forty-eight MS patients without symptoms of optic neuritis and forty-eight healthy control subjects were selected. Swept-source optical coherence tomography (SS-OCT) was performed using a DRI (deep-range imaging) Triton OCT device (Topcon Corp., Tokyo, Japan). Mean values (right and left eye) for macular thickness (retinal and choroidal layers) and peripapillary area (retinal nerve fibre layer, retinal, ganglion cell layer—GCL, and choroidal layers) were compared between both groups. Based on the analysis of the area under the receiver operator characteristic curve (AUC), the 3 variables with the greatest discriminant capacity were selected to form the feature vector. A SVM was used as an automatic classifier, obtaining the confusion matrix using leave-one-out cross-validation. Classification performance was assessed with Matthew’s correlation coefficient (MCC) and the AUCCLASSIFIER. The most discriminant variables were found to be the total GCL++ thickness (between inner limiting membrane to inner nuclear layer boundaries), evaluated in the peripapillary area and macular retina thickness in the nasal quadrant of the outer and inner rings. Using the SVM classifier, we obtained the following values: MCC = 0.81, sensitivity = 0.89, specificity = 0.92, accuracy = 0.91, and AUCCLASSIFIER = 0.97. Our findings suggest that it is possible to classify control subjects and MS patients without previous optic neuritis by applying machine-learning techniques to study the structural neurodegeneration in the retina.

BackgroundThe response of many biomedical systems can be modelled using a linear combination of damped exponential functions. The approximation parameters, based on equally spaced samples, can be obtained using Prony’s method and its variants (e.g. the matrix pencil method). This paper provides a tutorial on the main polynomial Prony and matrix pencil methods and their implementation in MATLAB and analyses how they perform with synthetic and multifocal visual-evoked potential (mfVEP) signals.This paper briefly describes the theoretical basis of four polynomial Prony approximation methods: classic, least squares (LS), total least squares (TLS) and matrix pencil method (MPM). In each of these cases, implementation uses general MATLAB functions. The features of the various options are tested by approximating a set of synthetic mathematical functions and evaluating filtering performance in the Prony domain when applied to mfVEP signals to improve diagnosis of patients with multiple sclerosis (MS).ResultsThe code implemented does not achieve 100%-correct signal approximation and, of the methods tested, LS and MPM perform best. When filtering mfVEP records in the Prony domain, the value of the area under the receiver-operating-characteristic (ROC) curve is 0.7055 compared with 0.6538 obtained with the usual filtering method used for this type of signal (discrete Fourier transform low-pass filter with a cut-off frequency of 35 Hz).ConclusionsThis paper reviews Prony’s method in relation to signal filtering and approximation, provides the MATLAB code needed to implement the classic, LS, TLS and MPM methods, and tests their performance in biomedical signal filtering and function approximation. It emphasizes the importance of improving the computational methods used to implement the various methods described above.

Nowadays, Artificial Intelligence (AI) is growing by leaps and bounds in almost all fields of technology, and Autonomous Vehicles (AV) research is one more of them. This paper proposes the using of algorithms based on Deep Learning (DL) in the control layer of an autonomous vehicle. More specifically, Deep Reinforcement Learning (DRL) algorithms such as Deep Q-Network (DQN) and Deep Deterministic Policy Gradient (DDPG) are implemented in order to compare results between them. The aim of this work is to obtain a trained model, applying a DRL algorithm, able of sending control commands to the vehicle to navigate properly and efficiently following a determined route. In addition, for each of the algorithms, several agents are presented as a solution, so that each of these agents uses different data sources to achieve the vehicle control commands. For this purpose, an open-source simulator such as CARLA is used, providing to the system with the ability to perform a multitude of tests without any risk into an hyper-realistic urban simulation environment, something that is unthinkable in the real world. The results obtained show that both DQN and DDPG reach the goal, but DDPG obtains a better performance. DDPG perfoms trajectories very similar to classic controller as LQR. In both cases RMSE is lower than 0.1m following trajectories with a range 180-700m. To conclude, some conclusions and future works are commented.

The interest in fisheye cameras has recently risen in the autonomous vehicles field, as they are able to reduce the complexity of perception systems while improving the management of dangerous driving situations. However, the strong distortion inherent to these cameras makes the usage of conventional computer vision algorithms difficult and has prevented the development of these devices. This paper presents a methodology that provides real-time semantic segmentation on fisheye cameras leveraging only synthetic images. Furthermore, we propose some Convolutional Neural Networks(CNN) architectures based on Efficient Residual Factorized Network(ERFNet) that demonstrate notable skills handling distortion and a new training strategy that improves the segmentation on the image borders. Our proposals are compared to similar state-of-the-art works showing an outstanding performance and tested in an unknown real world scenario using a fisheye camera integrated in an open-source autonomous electric car, showing a high domain adaptation capability.

No abstract