Background
Sedative premedication with benzodiazepines has been linked with prolonged recovery and inadequate emergence during the immediate postoperative period. We aimed to analyze the association between postanesthesia care unit (PACU) delirium and sedative premedication with oral midazolam.
Methods
We performed a secondary analysis of prospectively collected data before (midazolam cohort) and after (non-midazolam cohort) implementation of a restrictive strategy for oral premedication with midazolam. From March 2015 until July 2018, we included patients 60 years and older, who underwent elective radical prostatectomy for prostate cancer. Exclusion criteria were contraindications to premedication with midazolam, preoperative anxiety, and a history of neurological disorders. Patients, who were scheduled for postoperative admission to the intensive care unit, were excluded. Between 2015 and 2016, patients received 7.5 mg oral midazolam preoperatively (midazolam cohort). Patients included between 2017 and 2018 did not receive any sedative medication preoperatively (non-midazolam cohort). The primary endpoint was the incidence of PACU delirium.
Results
PACU delirium rates were 49% in the midazolam cohort (n = 214) and 33% in the non-midazolam cohort (n = 218). This difference was not statistically significant on multivariable logistic regression analysis (OR 0.847 [95% CI 0.164; 4.367]; P = 0.842). Age (OR 1.102 [95% CI 1.050; 1.156]; P < 0.001), the cumulative dose of sufentanil (OR 1.014 [95% CI 1.005; 1.024]; P = 0.005), and propofol-sufentanil for anesthesia maintenance (OR 2.805 [95% CI 1.497; 5.256]; P = 0.001) were significantly associated with PACU delirium.
Conclusion
Midazolam for sedative premedication was not significantly associated with PACU delirium. The reduction in the incidence of PACU delirium throughout the study period may be attributable to improvements in perioperative management other than a more restrictive preoperative benzodiazepine administration.
ZusammenfassungDie Leitlinien des European Resuscitation Council (ERC), die 2021 veröffentlicht wurden, empfehlen eine aktive Temperaturkontrolle zwischen 32 und 36 °C für alle erwachsenen Patient:innen, die nach Wiedererlangen des Spontankreislaufs nach prä- oder innerklinischer Reanimation das Bewusstsein nicht wiedererlangen.Wenige Wochen nach Veröffentlichung der Leitlinien 2021 wurde die TTM2-Studie publiziert, in der kein signifikanter Unterschied im Hinblick auf das Überleben oder das funktionelle Outcome nach sechs Monaten zwischen einer Zieltemperatur von 33 °C und einer Fiebervermeidung nach außerklinischem Herz-Kreislauf-Stillstand festgestellt worden war.Als Antwort auf die zusätzliche Evidenz durch die TTM2-Studie nahm die Advanced Life Support Task Force des International Liaison Committee on Resuscitation (ILCOR) eine Reevaluation der aktuellen Datenlage vor, die in einer überarbeiteten Empfehlung zur Temperaturkontrolle nach Herz-Kreislauf-Stillstand bei Erwachsenen resultierte. Der aktuelle Artikel fasst die aktualisierten Leitlinien zusammen und diskutiert kritische Aspekte der neuen Empfehlungen.
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