This study investigated processing effort by measuring peoples' pupil diameter as they listened to sentences containing a temporary syntactic ambiguity. In the first experiment, we manipulated prosody. The results showed that when prosodic structure conflicted with syntactic structure, pupil diameter reliably increased. In the second experiment, we manipulated both prosody and visual context. The results showed that when visual context was consistent with the correct interpretation, prosody had very little effect on processing effort. However, when visual context was inconsistent with the correct interpretation, prosody had a large effect on processing effort. The interaction between visual context and prosody shows that visual context has an effect on online processing and that it can modulate the influence of linguistic sources of information, such as prosody. Pupillometry is a sensitive measure of processing effort during spoken language comprehension.

Mindfulness meditation training has been shown to increase resting-state functional connectivity between nodes of the frontoparietal executive control network (dorsolateral prefrontal cortex [DLPFC]) and the default mode network (posterior cingulate cortex [PCC]). We investigated whether these effects generalized to a Mindfulness-Based Stress Reduction (MBSR) course and tested for structural and behaviorally relevant consequences of change in connectivity. Healthy, meditation-naïve adults were randomized to either MBSR (N = 48), an active (N = 47) or waitlist (N = 45) control group. Participants completed behavioral testing, resting-state fMRI scans and diffusion tensor scans at pre-randomization (T1), post-intervention (T2) and ~5.5 months later (T3). We found increased T2–T1 PCC–DLPFC resting connectivity for MBSR relative to control groups. Although these effects did not persist through long-term follow-up (T3–T1), MBSR participants showed a significantly stronger relationship between days of practice (T1 to T3) and increased PCC–DLPFC resting connectivity than participants in the active control group. Increased PCC–DLPFC resting connectivity in MBSR participants was associated with increased microstructural connectivity of a white matter tract connecting these regions and increased self-reported attention. These data show that MBSR increases PCC–DLPFC resting connectivity, which is related to increased practice time, attention and structural connectivity.

Empathy, the ability to understand others’ emotions, can occur through perspective taking and experience sharing. Neural systems active when adults empathize include regions underlying perspective taking (e.g. medial prefrontal cortex; MPFC) and experience sharing (e.g. inferior parietal lobule; IPL). It is unknown whether adolescents utilize networks implicated in both experience sharing and perspective taking when accurately empathizing. This question is critical given the importance of accurately understanding others’ emotions for developing and maintaining adaptive peer relationships during adolescence. We extend the literature on empathy in adolescence by determining the neural basis of empathic accuracy, a behavioral assay of empathy that does not bias participants toward the exclusive use of perspective taking or experience sharing. Participants (N = 155, aged 11.1–15.5 years) watched videos of ‘targets’ describing emotional events and continuously rated the targets’ emotions during functional magnetic resonance imaging scanning. Empathic accuracy related to activation in regions underlying perspective taking (MPFC, temporoparietal junction and superior temporal sulcus), while activation in regions underlying experience sharing (IPL, anterior cingulate cortex and anterior insula) related to lower empathic accuracy. These results provide novel insight into the neural basis of empathic accuracy in adolescence and suggest that perspective taking processes may be effective for increasing empathy.

The ability to understand emotional experiences of others, empathy, is a valuable skill for effective social interactions. Various types of training increase empathy in adolescents, but their impact on brain circuits underlying empathy has not been examined. Video games provide a unique medium familiar and engaging to adolescents and can be used to deliver training at scale. We developed an empathy training video game, Crystals of Kaydor (Crystals), and investigated whether playing Crystals increases empathic accuracy (EA) and related brain activation in adolescents (N = 74; 27 female; mean age(sd) = 12.8(0.7) years; age range 11–14 years). Participants completed a resting state functional MRI (rs-fMRI) scan and an EA task during an fMRI scan before and after 2 weeks of daily gameplay with either the empathy training game, Crystals (N = 34), or the commercial video game Bastion (N = 40), an active control condition. There were no group differences in EA improvement following gameplay, however, engagement with training aspects of Crystals was associated with a higher increase in EA-related activation in right temporoparietal junction following gameplay. Moreover, rs-fMRI connectivity in empathy-related brain circuits (posterior cingulate–medial prefrontal cortex; MPFC) was stronger after Crystals gameplay compared to Bastion. The more individuals’ EA increased following Crystals versus Bastion, the stronger their rs-fMRI connectivity in brain circuits relevant for emotion regulation (amygdala-MPFC). These findings suggest that a video game designed to increase empathic accuracy produces behaviorally-relevant, functional neural changes in fewer than 6 h of gameplay in adolescents.

Routine human behavior has often been attributed to plans-mental representations of sequences goals and actions-but can also be attributed to more opportunistic interactions of mind and a structured environment. This study asks whether performance on a task traditionally analyzed in terms of plans can be better understood from a "situated" (or "embodied") perspective. A saccade-contingent display-updating paradigm is used to change the environment by adding, deleting, and moving task-relevant objects without participants' direct awareness. Response latencies, action patterns, and eye movements all indicate that performance is guided not by plans stored in memory but by a control routine bound to objects as needed by perception and selective attention. The results have implications for interpreting everyday task performance and particular neuropsychological deficits.