Relevance. The high incidence of diseases of the liver and other organs of digestion in employees of State Fire Service of EMERCOM of Russia results from exposure to harmful chemical factors when performing professional tasks. Currently, the growing interest of the medical scientific community and practitioners is the nutritional support for the treatment of diseases of the digestive system. Therefore, the study aimed at substantiating the effectiveness of nutritional support in the treatment of liver diseases is certainly relevant.Intention. To scientifically substantiate effectiveness of enteral nutrition in the treatment of patients with liver diseases. Method. From 2015 to 2018, 237 patients, middle-aged men (56.4 ± 9.4) years, with liver diseases and trophic insufficiency of moderate severity were examined. All subjects were divided into 2 groups, the first group consisted of 121 people receiving enteral nutrition with Nutricomp HEPA liquid, the second group consisted of 116 people treated without enteral support. To assess the effectiveness of enteral nutrition in the treatment of liver diseases, the following were analyzed: trophological status, biochemical parameters of the protein fraction of peripheral blood, proteins of the blood coagulation system and the activity of transaminases. The indicators of self-assessment of quality of life before and after treatment were also analyzed.Results and Discussion. Nutraceuticals, compared to no enteral nutrition, significantly reduced the concentrations of ammonia, increased concentrations of albumin, product of protein metabolism, indicators of blood coagulation and the activity of transaminases. They have significantly increased body mass index, and body mass deficit decreased. After treatment with enteral nutrition in patients, self-assessment of quality of life was significantly higher than in the group not receiving enteral nutrition.Conclusion. Thus, the use of nutraceuticals for enteral support of patients with reduced trophological status can significantly improve the effectiveness of therapy, promotes faster recovery and reduces time spent in hospital.
Comparative evaluation of sexual development among adolescent girls whose mothers experienced and did not experience psychological trauma associated with life-threatening was conducted. The physiological features of sexual development in girls in the Republic of Dagestan, whose mothers experienced a high risk of terror threat in pregravidarum period were identified. It was determined that in pre-pubertal period the concentration of luteinizing and follicle-stimulating hormone in peripheral blood in girls whose mothers experienced stress associated with life-threatening was significantly higher than in girls of the control group. In prepubertal period in girls whose mothers experienced a vital stress, the earlier decrease in the activity of the adrenal cortex in the transition from prepuberty to puberty was observed. Girls whose mothers experienced a vital stress can be characterized by an earlier menarche, at the age of 10-12 the menarche occurred significantly more often than in the control group. The anthropometric data show an earlier maturation of these girls under the age of 12. In the prepubertal period the formation of breast and pubic hair growth were ahead of girls in the control group. Thus, girls whose mothers experienced vital stress are characterized by an earlier and at the same time disharmonious puberty. They are characterized by earlier menarche, delayed rhythm of the menstrual cycle and some changes in humoral regulation rhythm. Thus, it is vital the stress suffered by women before pregnancy causes changes in hormonal regulation in pregnancy that leads to long-term damage of physiological homeostasis of the offspring.
1 ФКГУ «1586 Военный клинический госпиталь» министерства обороны Российской Федерации, Подольск; 2 ФГКВоУ ВПо «Военно-медицинская академия им. С. м. Кирова» министерства обороны России, Санкт-Петербург; 3 ГБоУ ВПо «Санкт-Петербургский государственный педиатрический медицинский университет» минздрава России; 4 ФБГУ «Научно-исследовательский институт экспериментальной медицины» СЗо РАмН, Санкт-Петербург Резюме. Проведен анализ психоэмоционального статуса и гомеостаза у женщин с первичной дисменореей, проходивших военную службу в экстремальных условиях Приднестровья. Оценка степени выраженности не-вротических синдромов свидетельствует, что женщины-военнослужащие с нарушениями менструального цик-ла характеризуются выраженной аффективной лабильностью, астеническими и депрессивными проявлениями, аффективной напряженностью и инсомниями. Выявлены разнонаправленные изменения форменных элементов периферической крови, биохимических показателей и показателей содержания гормонов в сыворотке крови у женщин данного контингента. Определено, что у женщин-военнослужащих нарушение менструального цикла по типу дисменореи связано с повышением концентрации кортизола и тенденцией к повышению пролактина, в то время как у женщин гражданского населения с повышением фолликулостимулирующего гормона. Женщины-во-еннослужащие, участники боевых действий, страдающие дисменореей характеризуются метаболическими на-рушениями с превалированием катаболических реакций и изменением спектра липидов плазмы крови, о чем свидетельствуют достоверно более низкие показатели холестерина липопротеидов высокой плотности и более высокие -триглицеридов относительно группы контроля. Определена взаимосвязь невротических синдромов и особенностей гормональной регуляции у женщин-военнослужащих. Нейрофармакологический анализ показал увеличение эффективности лечебных мероприятий на фоне приема антидепрессантов у женщин, переживших витальный стресс, что позволяет предположить вовлечение моноаминовых систем головного мозга в формиро-вание данной гинекологической патологии.Ключевые слова: психогенно обусловленные расстройства; боевой стресс; первичная дисменорея; витальная угроза; экстремальные факторы; посттравматические стрессовые расстройства. Abstract. The analysis of psycho-emotional status and homeostasis rates in women with primary dysmenorrheal who have done military service in the extreme conditions in Transdniestria has been performed. Assessment of the severity of neurotic syndromes suggests that women soldiers with the menstrual cycle are characterized by marked affective lability, asthenic and depressive symptoms, affective tensions and insomnias. The multidirectional changes in peripheral blood corpuscles, biochemistry rates and the blood serum hormone rates in women of given community have been revealed. It was determined that military women have menstrual cycle disorders classified as dysmenorrheal that is related to the increase of cortisol concentration and the trend to prolactine increase, while female civilians this disease is related to the increase of...
The analysis of case histories and ambulatory cards of women from different districts of the Republic of Dagestan. Women experienced psychological trauma in puberty metabolic disorders are manifested by increased glucose level and decrease high density lipoproteins. Violation of reproductive function in women who have experienced psychological trauma high risk of terrorist threat, due to the increase in the concentration of cortisol, prolactin and a decrease in luteinizing hormone and estradiol. Revealed that women exposed to mental trauma associated with a high risk of a terrorist threat in the pubertal period compared to women from areas powerassist attack, developed stressinducing immunity disorders manifested in the reduction of amount of b-cell populations system immune system Supplement available, increased levels of IFN-g and TNF-α and decrease in IL-4 and IL-6. It is proved that the key mechanisms of pathology of the reproductive system are dysregulation of the immune and endocrine. (For citation: Temirkhanova KT, Tsykunov SG, Pyatibrat ED, et al. Mechanisms of disorders of the reproductive function in women of the Republic of Dagestan survived the vital stress. Reviews on Clinical Pharmacology and Drug Therapy. 2017;15(2):73-79. doi: 10.17816/RCF15273-79).
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