Hyperandrogenism is a condition affecting 5-10% of adolescents. The aim of this study was to evaluate the efficacy of very low dose of flutamide in the treatment of hyperandrogenism in adolescence. One hundred and fifty-eight patients, presenting severe acne and/or hirsutism, received 62.5 mg/day of flutamide + ethinylestradiol + gestodene for 18 months. The patients were subjected to assessments of hepatic enzymes levels. Thirty subjects treated with drospirenone + ethinylestradiol represented the control group. After 18 months of treatment, it was obtained a decrease of hirsutism (-39.9%), an almost recovery of acne (98% of patients) with better results of those obtained in control group. Only one case of light hypertransaminasemia was recorded, regressed spontaneously. Very low dose of flutamide was successful and safe and in the treatment of hyperandrogenism in adolescence.
Objective: To evaluate the diagnostic, therapeutic and prognostic aspects of ectopic pregnancy at the Regional Hospital of Thiès.
Methods and Materials:This is a prospective and descriptive study of patients received for Ectopic Pregnancy (EP) and managed in the gynecology and obstetrics department of the regional hospital of Thiès between 1 July 2013 and 31 December 2014. Diagnostic, therapeutic and prognostic aspects were studied. The data was compiled entered and analyzed using the Sphinx version 5 software.
Results:We registered 50 EPs from 695 patients presenting with metrorrhagia in the first trimester, which represents a frequency of 7.2%.The epidemiological profile of the patients was that of a 29 years woman on average, few previous deliveries (28%) and referrals (48%). For the most part it involved a ruptured EP (92%) and of ampulla location (78%). Forty-nine patients (98%) had surgical treatment including 45 salpingectomies (90%). We had one maternal death, representing a 2% mortality rate. Fertility after EP was 33%.Conclusion: EP remains a frequent condition in our hospital. The majority of patients arrive in a state of raptured EP requiring radical surgical interventions
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