A case-control study on dietary factors and colorectal adenomas was conducted in the island of Majorca, Spain, from April 1987 to February 1990. Subjects were interviewed using a food frequency questionnaire. Nutrient and caloric intake was estimated using local food composition tables. The risk of colorectal adenomas was related to the consumption of sugar and pastries. Consumption of vegetables was highly protective, irrespective of the cooking procedures. Analyses by nutrients identified as protective factors ftber from fruits and vegetables, magnesium and zinc, and vitamins C, B, and folk acid. No excess risk was found for alcohol drinking, intake of saturated fats or animal protein. Of the non-dietary factors, sedentariness in the workplace and urban residence were the only risk factors identified.o 1993 Wiley-Liss, Inc.Neoplastic transformation of the colonic mucosa is accepted as a multi-stage process involving celI proliferation, adenoma formation and growth, malignant transformation and invasion (Fearon and Vogelstein, 1990). Host genetic factors have been reported to be related to the neoplastic process (Vogelstein et aZ., 1988) and epidemiological studies have identified dietary risk factors for colorectal cancer and adenomas. However, it remains uncertain which dietary factors are relevant in each of the proposed intermediate stages and it has been suggested that different factors might operate in each step in the neoplastic process (Hill et al., 1978;Faivre and Boutron, 1991; Cannon-Albright et al., 1988). In the US, a prospective study on adenomas of the left colon and rectum in males revealed an increased risk associated with diets rich in saturated fats and low in fiber, with a strong protective effect of fiber irrespective of food source (Giovanucci et al., 1992). These results are consistent with the hypothesis that the same dietary factors operate in colorectal cancer and in its precursors. Meat consumption, one of the commonest described risk factors for colorectal cancer, has been linked to a lower risk of colonic adenoma in Japan (Kato et al., 1990) and to a high risk in the US (Neugut et al., 1993;Giovannucci et al., 1992).Increased risk of colonic adenomas has been linked to the consumption of sugar and sweets (Macquart-Moulin et al., 1987) and cheese (Neugut et al., 1993) and a reduction in risk has been linked to high consumption of potatoes and oil (Macquart-Moulin et al., 1987), fish (Kato et al., 1990), and fruit and vegetables (Giovannucci et al., 1992;Hoff et al., 1986; Kato et al., 1990; Neugut et al., 1993). Several studies have reported an increased risk linked to alcohol consumption (Kikendall et al., 1989;Stemmermann et al., 1988; Kato et al., 1990;Kono et al., 1990; Cope et al., 1991), although the effect has not been found consistently (Giovannucci et al., 1992; Riboli et al., 1991).Studies on dietary risk factors for colorectal adenomas serve the double purpose of describing the dietary factors involved in stages of the continuum from normal mucosa to cancer and of p...