We present the updated British Association for Sexual Health and HIV guidelines for HIV post-exposure prophylaxis following sexual exposure (PEPSE). This document includes a review of the current data to support the use of PEPSE, considers how to calculate the risks of infection after a potential exposure, and provides recommendations on when PEPSE should and should not be considered. We also review which medications to use for PEPSE, provide a checklist for initial assessment, and make recommendations for monitoring individuals receiving PEPSE. Special scenarios, cost-effectiveness of PEPSE, and issues relating to service provision are also discussed. Throughout the document, the place of PEPSE within the broader context of other HIV prevention strategies is considered.

SummaryA controlled prospective survey of women taking oestrogen-progestogen oral contraceptives showed increases in mean systolic and diastolic blood pressure of 14-2 mm Hg and 8-5 mm Hg respectively after four years. The largest increases in individual cases were 36 mm Hg systolic and 20 mm Hg diastolic. Blood pressure returned to pretreatment levels within three months after oral contraceptives had been stopped. These changes in blood pressure were unrelated to the progestogenic potencies of the preparations being taken.

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During a 10-month period, 250 unmarried girls presented to the Glasgow Advisory Centre (G.A.C.), thinking that they were pregnant, and in 210 cases, pregnancy was confirmed. In 88 of these 210 girls, it was known that termination of the pregnancy was carried out, either in Glasgow or in England. Five girls were known to continue with the pregnancy, while the remaining 117 defaulted from further attendance and their outcome could not therefore be determined. Some of the problems associated with termination of pregnancy in the unmarried have been discussed including the workings of the Abortion Act, the role of the General Practitioner and the lack of facilities in the Glasgow area, both for the provision af advice and the performance of termination.

The What Works Movement in the UK Government has seen the establishment of 12 centres to focus on evidence-based policy in different domains. In this paper, we present the challenges and opportunities posed by a What Works Centre (WWC) for Probation, based on our prior experience of establishing WWCs in other areas. Although there are legitimate and substantial challenges to some of the methodological approaches of ‘What Works’, we conclude that Probation is in an unusually strong starting position for such a centre to thrive.

An attempt was made to assess the potential use of holography in information storage and retrieval systems. Various scientific (physics), engineering, and business indexes were searched as well as those dealing with information science and libraries. A great many articles were found in the first three, all of which indicate the vast amount of interest, research, and development in the field, and lead to the conclusion that holography is one of the most promising methods now under research for the achievement of high bulk storage with fast random access at a reasonable cost. Because such a method implies a far greater than present ability to store, access, and transmit information on the part of information centers and libraries, and because little has been written in their literature, this paper has been prepared as a “state of the art” to provide background knowledge which is expected to be useful to many in the future.

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