Neurofibroma is an uncommon benign tumor of the oral cavity derived from the cells that constitute the nerve sheath. The cases of oral cavity involvement by a solitary and peripheral plexiform neurofibroma in patients with no other signs of neurofibromatosis is uncommon. Sporadic cases have been reported in the submandibular gland, tongue and on the periosteum at the mental foramen. The World Health Organization (WHO) has subdivided neurofibromas into two broad categories: dermal and plexiform. The dermal neurofibromas arise from a single peripheral nerve, while the plexiform neurofibromas are associated with multiple nerve bundles. The aim of this paper is to analyze the effectiveness of diode laser in the treatment of neurofibroma of a solitary lesion on the tongue. The advantages of using lasers in this case report was a bloodless and painless experience for the patient with excellent healing of the operated site after a period of 1 week.
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