Objective Interleukin-6 (IL-6) is an important cytokine that plays a key role in the immune system. Changes in the immune system, particularly increased IL-6 concentrations, have been reported in schizophrenia (SCZ) patients. Although this cytokine needs its receptor (IL-6R) to function properly, few studies have examined IL-6R polymorphisms and the risk of SCZ. The aim of the present study was to evaluate the possible association between IL-6R polymorphisms (rs2229238 and rs4845625) and susceptibility to SCZ. Methods A case-control study was carried out including 92 SCZ patients and 92 healthy controls. Two single-nucleotide polymorphisms were genotyped using amplification-refractory mutation system polymerase chain reaction. Results It was found that the TC genotype of rs4845625 and CT and TT of rs2229238 increased the SCZ risk (OR 2.691, 95% CI 1.075-6.736, P = 0.034; OR 4.273, 95% CI 1.937-9.433, P < 0.001; and OR 2.123, 95% CI 1.071-4.219, P = 0.031, respectively). In dominant genetic model analysis, it was found that CT+TT of rs2229238 and TC+CC of rs4845625 were associated with the risk of SCZ (OR 2.762, 95% CI 1.426-5.376, P = 0.003 and OR 2.824, 95% CI 1.545-5.154, P < 0.001, respectively). Conclusions The findings showed that the rs2229238 and rs4845625 singlenucleotide polymorphisms were prominently associated with SCZ. Further studies are required to confirm the findings.
Melatonin has an important role in the regulation of human sleep circadian rhythms. Sleep disturbances commonly exist in schizophrenia (SCZ) patients. To begin its performance, melatonin must interact to its receptor. In the present study, Single Nucleotide Polymorphisms (SNPs) of melatonin receptor gene 1 B (MTN1B) with SCZ development in Iranian population were investigated. The current case-control study was performed on 92 SCZ patients and 92 healthy control (HC) subjects. NESTED-PCR and ARMS-PCR modified methods (combination) and ARMS-PCR method were used on the genotype. The impact of MTN1B rs3781637 (T/C) and rs10830963(C/G) polymorphism variants on the risk SCZ in the sample of Iranian population was investigated. The findings showed significant association between MTN1B rs10830963(C/G) variant and SCZ (OR=2.78, P=0.012, GG vs. CC, OR=1.66, P=0.021 G vs. C, P<0.0001, GG vs. CC+CG). There was no association between MTN1B rs3781637 (T/C) and SCZ risk. In addition, haplotype analysis revealed that TG and CC haplotype of rs3781637 (T/C) and rs10830963 (C/G) polymorphisms
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.