LECUBE, ALBERT, ALICIA CARRERA, ELADIO LOSADA, CRISTINA HERNÁ NDEZ, RAFAEL SIMÓ , AND JORDI MESA. Iron deficiency in obese postmenopausal women. Obesity. 2006;14:1724 -1730. Objective: This study evaluates whether the iron deficiency suggested in children and adolescents with overweight is also present with increasing age. Research Methods and Procedures:We examined 50 consecutive postmenopausal nondiabetic white women with a BMI Ն30 kg/m 2 and 50 non-obese seemingly healthy women as a control group. In addition to the traditional indices of iron status, we measured the soluble transferrin receptor (sTfR) levels, a sensitive and highly quantitative indicator of early iron deficiency not influenced by the acute phase response. Results: Obese women have higher serum sTfR levels than control subjects [1.38 (range, 0.89 to 2.39) vs. 1.16 mg/dL (range, 0.69 to 2.03 mg/dL); p Ͻ 0.001]. However, no difference in ferritin concentration was observed between the groups [70.50 (range, 18 to 219) vs. 69.50 ng/mL (range, 24 to 270 ng/mL); p ϭ not significant]. A positive correlation between BMI and sTfR concentration was detected. On multiple regression analyses, BMI (positively) and ferritin (inversely) were independent predictors accounting for sTfR. Discussion: These results suggest that a moderate degree of iron deficiency is also present among adult women with obesity. The determination of sTfR is useful in the evaluation of iron status in this condition. Further studies with a greater number of patients are required to investigate the relationship between tissue iron concentrations and obesity.

Insulin monotherapy was associated with an increased fracture risk compared to MTF monotherapy in T2DM patients. Fracture risk should be taken into account when starting a glucose-lowering drug as part of T2DM treatment.

Diabetic patients with blurred vision after starting insulin therapy present a significant transient increase in macular biometrics which is associated with a decrease in circulating sFlt-1.

Normoalbuminuric type 1 diabetic patients with DR have impaired renal response to dDAVP that is related to plasma ET-1 levels. Further studies are required to elucidate whether this tubular resistance to dDAVP might favor dehydration in these patients.

Objective: Global thyroid cancer (TC) incidence is growing worldwide, but great heterogenicity exists among published studies and thus, population-specific epidemiological studies are needed to adequate health resources and evaluate impact of overdiagnosis. Methods: We conducted a Public Health System database retrospective review of TC incident cases from 2000 to 2020 in the Balearic Islands region and evaluated age-standardized incidence (ASIR), age at diagnosis, gender distribution, tumor size and histological subtype, mortality rate (MR) and cause of death. Estimated annual percent changes (EAPCs) were also evaluated and data from the 2000-2009 period was compared to the 2010-2020, when neck ultrasound (US) was routinely performed by clinicians at Endocrinology Departments. Results: A total of 1,387 incident cases of TC were detected. Overall, ASIR (x105) was 5.01 with a 7.82% increment in EAPC. A significant increase in the 2010-2020 period was seen for ASIR (6.99 vs. 2.82, p<0.001) and age at diagnosis (52.11 vs. 47.32, p<0.001) compared to the 2000-2009 period. A reduction in tumor size (2.00 vs 2.78 cm, p<0,001) and a 6.31% increase in Micropapillary TC (p<0.05) were also seen. Disease-specific MR remained stable at 0.21 (x105). Mean age at diagnosis for all mortality groups was older than survivors (p<0.001). Conclusion: Incidence of TC has grown in the 2000-2020 period in the Balearic Islands, but mortality rate has not changed. Beyond other factors, a significant contribution of overdiagnosis to this increased incidence is likely, due to changes in the routine management of thyroid nodular disease and increased availability of neck US.

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