Background: Contrast-induced nephropathy (CIN) is a serious complication of angiographic procedures and results from administration of iodinated contrast media (CM). Aim: To study the preventive and therapeutic effects of Mineralocorticoid receptor antagonist's pretreatment on contrast-induced acute kidney injury in patients undergoing coronary angioplasty. Methods: This case control study was carried out on patients admitted for coronary angioplasty in Benha University Hospitals (cardiology department), in which 100 patients were selected and divided in two groups "active & control". Group (A)(control): received placebo. Group (B) (Active): received Spironolactone 50 mg. Results: Blood Urea in Group (A) showed a significant increase during follow up when it was compared to baseline values while Group (B) showed an increase during follow up but without any statistically significant difference. Serum Creatinine in Group (A) showed a significant increase after 2 days of follow up with a mean value of 1.30±0.248 when it was compared to baseline values. While Group (B) showed a significant increase after 2 days of follow up with a mean value of 1.15±0.406 when it was compared to baseline values and also when compared to values after 7 days of follow up with a mean value of 1.19±0.384. Conclusion: The administering of Mineralocorticoid therapy prior to coronary angioplasty obtains additional benefit in terms of decrease incidence of CI-AKI in CAD patients.
Background:The hallmark of gout is hyperuricemia. This substance has ties to cardiovascular disease's pathophysiology, which is the main killer of dialysis patients. Diabetes, insulin resistance, and other cardiovascular diseases as well as hypertension are all linked to hyperuricemia. Death from any cause is prevented by high SUA levels. Smaller studies found Jshaped relationships between SUA and all-cause mortality. In line with its function in protein metabolism, a recent study suggests that SUA could be used as a nutritional status indicator in hemodialysis patients. Rather than a high SUA, a superior nutritional state may explain survival connections. In HD patients, LVH with diverse etiologies is predictive of CV mortality and morbidity. Aim: to investigate the relationship between left ventricular morphological and functional problems and preand post-dialysis uric acid differences in individuals receiving maintenance hemodialysis. Subject and Methods: This study was carried out on ESRD patients in Internal Medicine Department of Benha University in the hemodialysis unit, where 100 patients were selected. Results: There were high statistically significant differences between the studied patients systolic and diastolic blood pressure before and after hemodialysis. There were high statistically significant differences between the studied patient's serum level of uric acid, creatinine and urea before and after hemodialysis. Conclusion: This study found a strong relationship between uric acid and both LV parameters and ejection fraction. We discovered through regression analysis that serum uric acid was an important indicator of LV ejection fraction.
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