The most common skin disorder is acne (Acne vulgaris) which is a chronic inflammatory disease that occurs in the pilosebaceous unit. Infection can be caused by Propionibacterium acnes and Staphylococcus aureus. Moringa leaves are known to inhibit acne growth. Piper crocatum leaves are also thought to have antibacterial activity. The study aims to determine the effect of the combination of the two extracts in inhibiting the growth of acne-causing bacteria, also tested the gel formula to meet physical and chemical parameters as well as stability to temperature and storage, also to test the acute dermal irritation against rabbit. Each extract with a concentration of 0.3%; 0.6%; 1.25%; 2.5%; 5%; 10%; 20%, incubated then measured the inhibition zone, then determined the minimum inhibition zone concentration of the two extracts to determine the lowest levels of the extracts which still gave antibacterial activity against the tested bacteria by the well diffusion method. The extract combination was formulated in a gel preparation with the excipients Carbopol 940, PG, Phenoxyethanol, TEA, CMC, and Aquadest. Antibacterial activity test for gel preparations used the well method with positive control Medi-Klin® gel. Then the formula evaluation includes physical, chemical, and microbiological evaluations. The results showed that the combination gel form had activity against P. acne and S. aureus at concentrations of 2.5% : 2.5%. The combination gel preparation of the two extracts also has synergistic effect in inhibiting acne bacteria. The formula can meet physical and chemical parameters and is stable to temperature and storage.
Penuaan merupakan proses alami yang terjadi kepada setiap manusia dan dipengaruhi berbagai macam faktor dari dalam dan luar tubuh. Penuaan dapat disebabkan karena umur yang sudah tua, asupan nutrisi tidak cukup, hingga karena adanya radikal bebas pada kulit. Penuaan dapat dicegah atau diperlambat dengan penggunaan kolagen yang cukup, tepat, dan sesuai. Kolagen dapat diperoleh secara alami, salah satunya berasal dari tulang ayam. Penelitian ini menggunakan metode Literature Review Article Dengan mengkaji beberapa artikel atau literature yang berkaitan dengan tema tersebut, maka digunakan 5 jenis artikel baik nasional maupun internasional terbitan 10 tahun terakhir. Literature yang diperoleh merupakan artikel yang ditemukan menggunakan kata kunci Chicken bone as collagen source, tulang ayam sebagai sumber kolagen, limbah tulang ayam untuk antiaging, dan kolagen untuk antiaging yang bersumber dari tulang ayam. Berdasarkan pemaparan yang dilakukan, diketahui bahwa tulang ayam dapat menjadi sumber alternative kolagen untuk diaplikasikan pada kosmetik yang dapat mencegah atau memperlambat terjadinya penuaan pada kulit.
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