Six coumarin-caged compounds of 1-naphthaleneacetic
acid (NAA)
comprising different substituents on the coumarin moiety were synthesized
and evaluated for their photophysical and chemical properties as light-responsive
controlled-release plant root stimulators. The 1H NMR and
HPLC techniques were used to verify the release of NAA from the caged
compounds. After irradiation at 365 nm, the caged compounds exhibited
the fastest release rate at t
1/2 of 6.7
days and the slowest release rate at t
1/2 of 73.7 days. Caged compounds at high concentrations (10–5 and 10–6 M) significantly stimulate secondary
root germination while free NAA at the same level is toxic and leads
to inhibition of secondary root germination. The cytotoxicity of the
caged compounds against fibroblasts and vero cells were evaluated,
and the results suggested that, at 10–5–10–6 M, caged compounds exhibited no significant cytotoxicity
to the cells. Thus, the caged compounds of NAA in this study could
be of great benefit as efficient agrochemicals.
127I-modified mIBG was successfully synthesized and grafted covalently to the surface of carboxylated PEG-GNPs. The particles were not toxic to the normal fibroblast cells while specifically internalized into neuroblastoma cells line via NET.
Viral entry, the first process in the reproduction of viruses, primarily involves attachment of
the viral envelope proteins to membranes of the host cell. The crucial components that play an important
role in viral entry include viral surface glycoprotein gp120, viral transmembrane glycoprotein gp41, host
cell glycoprotein (CD4), and host cell chemokine receptors (CCR5 and CXCR4). Inhibition of the multiple
molecular interactions of these components can restrain viruses, such as HIV-1, from fusion with
the host cell, blocking them from reproducing. This review article specifically focuses on the recent progress
in the development of small-molecule HIV-1 entry inhibitors and incorporates important aspects of
their structural modification that lead to the discovery of new molecular scaffolds with more potency.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.