Breakdown of self-incompatibility has frequently been attributed to loss-of-function mutations of alleles at the locus responsible for recognition of self-pollen (i.e. the S-locus). However, other potential causes have rarely been tested. Here, we show that self-compatibility of S1S1-homozygotes in selfing populations of the otherwise self-incompatible Arabidopsis lyrata is not due to S-locus mutation. Between-breeding-system cross-progeny are self-compatible if they combine S1 from the self-compatible cross-partner with recessive S1 from the self-incompatible cross-partner, but self-incompatible with dominant S-alleles. Because S1S1 homozygotes in outcrossing populations are self-incompatible, mutation of S1 cannot explain self-compatibility in S1S1 cross-progeny. This supports the hypothesis that an S1-specific modifier unlinked to the S-locus causes self-compatibility by functionally disrupting S1. Self-compatibility in S19S19 homozygotes may also be caused by an S19-specific modifier, but we cannot rule out a loss-of-function mutation of S19. Taken together, our findings indicate that breakdown of self-incompatibility is possible without disruptive mutations at the S-locus.
Rendering of high-tech medical care (HTMC) is one of the priority directions of the Ministry of Health of the Russian Federation. Search of new organizational approaches, elaboration and perfection of medical technologies, introduction of new materials continue. The purpose of the study was to evaluate the expediency of biodegradable constructions use at rendering HTMC to traumatologic and orthopaedic patients. Treatment results for 56 patients with various feet pathology (calcaneus fractures, feet joints deforming arthrosis, Hallus valgus) were analyzed retrospectively. In control group ( n =28) metal constructions and in the main group (n=28) biodegradable constructions were used for bone fragments fixation. In two groups surgical treatment results were comparable, however treatment of patients from the main group was accompanied by significant social and economic effect due to more effective work of the bed as no construction removal was performed and no expenditures for patient’s stay at the hospital and intensive care unit were required. All that contributed to the improvement of patients’ life quality.
Objective. To analyze the outcomes of early rehabilitation of patients with consequences of spinal cord injury using robotic technology. Material and Methods. A total of 122 patients with consequences of spinal cord injury having movement disorders were examined and treated in the rehabilitation department of the Novosibirsk RITO. Group 1 included 59 patients treated with the standard version of rehabilitation program, while the program used in Group 2 (63 patients) involved longer and more careful preparation for sessions on the Lokomat machine and consisted of three stages of treatment-prehospital, preliminary and main ones. Results. The course of rehabilitation therapy had positive effect on the dynamics of neurological symptoms. Indicators of positive dynamics were statistically significantly higher in patients of Group 2. Data of electrophysiological study also showed that the optimized treatment program was more effective in restoring lost functions of the spinal cord. Optimization of rehabilitation and preconditioning of patients to loads decreased frequency of adverse reactions (orthostatic and fever responses, increase in pyramidal muscle tone in lower extremities) in comparison with the standard approach. Conclusion. Optimized course of rehabilitation therapy positively affected the dynamics of neurological symptoms.
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