Background. The effective treatment of oncological diseases requires the proper organization of interdisciplinary communication between specialists. Such an approach should be implemented in educational events organized by professional communities.
Aim. To analyze the effectiveness of interaction between professional oncology communities and expert physicians on the platforms of educational events in Russia as a response to the unprecedented growth of scientific knowledge in oncology.
Materials and methods. We studied educational events programs organized by oncological communities. The keywords of the report titles in 2012 and 2021 and the features of the networking structure of the speakers at the educational events in 2021 were analyzed.
Results. In 2021, there was a significant expansion of the range of topics discussed compared to 2012, while experts began to use the terms "diagnosis", "prevention", "radiotherapy", and others much less frequently. The network structure of professional community interactions and interdisciplinary connections of experts at educational events is heterogeneous; some communities actively cooperate, while others show a closed position. At the level of systematic multidisciplinary expert interaction, there is also an underrepresentation of pathologists, geneticists, and other specialists.
Conclusion. The oncology professional community needs to regularly work on multidisciplinary consolidation of competencies and broad discussion of clinical experience at scientific and educational events.
Retinoblastoma (RB) is one of the most common malignant neoplasms of the visual organ in children, with an established genetic factor in the development of the disease. The detection of mutations in the RB1 gene has been successfully carried out for many years, however, the development of technologies for DNA diagnostics of RB allows us to consider this disease not only as an independent tumor, but also as one of the manifestations of more complicated genetic syndromes involving a complex of genes. The correct genetic diagnosis is important to understand the prognosis of the health of a patient with RB and recommendations for his further observation, as well as a correct assessment of the risks of having children with the same pathology in the family.Currently available methods of DNA diagnostics of the RB1 gene are new generation sequencing (NGS) and multiplex amplification of ligated probes (MLPA). However, in some cases, additional diagnostics may be required – a karyotype study or chromosomal micromatrix analysis (CMA). In this article we present a molecular genetic study of children with uni- and bilateral RB with an extended deletion at the RB1 gene locus. The aim of the study was determining of possible indications for the appointment of extended DNA diagnostics.
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