Arylative annulation of 2-carbonyl-3-propargyl indoles with boronic acids under sequential palladium/triflic acid catalysis is described. The present strategy to provide di-and triaryl carbazoles in one pot involves benzannulation through difunctionalization of alkynes. The strategy showed a good substrate scope with respect to boronic acids as well as 2-carbonyl-3-propargyl indoles to afford the corresponding carbazoles in decent yields.
Rh(III)-catalyzed cascade oxidative CÀ H functionalization/aza-annulation of indole and pyrrole-N-carboxamides with 1,3-enynes involving 1,4-rhodium migration is disclosed. This [4 + 1] annulation protocol provides an approach for the synthesis of imidazo[1,5-a]indol-3(2H)-ones from easily accessible substrates. Moreover, sulfonamides are also found to be well compatible in this method, leading to the corresponding benzo [d]sultams. The efficacy of this protocol is highlighted by handy downstream conversions of the dienyl-sultam.
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