The clinical effect of cis(Z)-clopenthixol has been compared with that of clopenthixol, which is a mixture of the pharmacologically active cis(Z)-isomer and the inactive trans(E)-isomer. In the 2-month double-blind trial were included 57 psychotic patients, mainly schizophrenics. Ratings evaluating severity of illness, therapeutic effect, possible interference of side effects with the patient's functioning, as well as any individual side effects were done at months 0, 1, and 2. The antipsychotic effect of cis(Z)-clopenthixol was found equal to that of clopenthixol whereas the cis(Z)-isomer on a mg/mg basis was twice as active as clopenthixol. Apart from the finding that the unspecific sedative effect appeared to be less marked with cis(Z)-clopenthixol, the type, degree, and frequency of side effects were the same in the two groups of patients. More than half of the patients experienced no side effects.
The mortality and the causes of death show no such differences which could justify conclusions of more frequent lethal complications in connection with any of the drugs used.The frequency of lethal complications previously described as typical for neuroleptica (agranulocytosis, toxic hepatosis and convulsions) was unexpectedly low.
Litteratur.Buronil og prornazinbehandling av senildemen te En dobbeltblind undersokelse.
E I N A R E N G S T R A N DPleien av senil-demente pasienter er et voksende problem som belaster mange sykehus. Pasientene er dels eldre psykotiske pasienter, ofte med en lang sykdomsvarighet, dels tidligere psykisk friske, gamle mennesker, som innlegges p& grunn av de store pleievanskeligheter disse piforer hjemmene og private institusjoner.Senil-demente, urolige pasienter behandles ofte med fentiazinderivater ( promazin, klorpromazin) eller klorprotixen. Behandlingen med disse stoffene medfrarer ganske ofte uranskede, generende virkninger, slledes .parkinsonismea, slavhet og visse kardiovaskulaere bivirkninger, f. eks. tachycardi og ortostatisk hypotensjon (7). I Nordisk Medicin (1 I ) er tidligere inntatt noen meddelelser som omtaler et nytt ataraxicum av butyrofenongruppen, BuronilQ, ti1 behandling af kronisk schizofreni og senil-demente pasienter. I det fdgende gis en Fra Veum sykehus (0stfold fylkes psykiatriske sykehus) Fredrikstad. Sjef : ouerlege A . Bretteville-Jensen. 234 Nord J Psychiatry Downloaded from informahealthcare.com by McMaster University on 11/03/14 For personal use only. * ) Preparatet fremstilles av Ferrosan, Ksbenhavn-Malma, og de omtalte preparater er velvilligst stillt ti1 ridighet av fabrikken, som ogsa har bistitt med tilretteleggingen av forssket. Nord J Psychiatry Downloaded from informahealthcare.com by McMaster University on 11/03/14For personal use only.
the material and, similarly, observations concerning special tendencies cannot he madc.A feature observed throughout all three was that depressions lasting from one to thrce months shoived thc poorest therapeutic results.
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