Background: Congenital heart defects (CHD) are the most common type of birth defects and remain the leading cause of death from congenital malformations.Objectives: To assess the parent's knowledge regarding diagnosis and management of their children with CHD.Methods: This is a prospective questionnaire based study, conducted in Ahmed Gasim cardiac Centre, A tertiary care centre in Khartoum state, the study period was from 1st June to 31st August of 2017.Results: The total study population was 120 children with congenital heart disease and their parents. Of these children, males were 65 (54.2%) and females were 55 (45.8%). The children's age ranged from 2months to 16years. The study showed that of these patients 76.7% had a cyanotic CHD with VSD being the commonest lesion found in 45% of them, while 23.3% of them had cyanotic CHD and TOF represented the most common lesion in 18.3% of them. For most of the parents the diagnosis of their children heart problem was explained to them, 78.3% of them knew correctly their children cardiac lesions, and 95.8% of them knew that it is congenital in origin, unfortunately 63.3% of them did not know the name of their children drugs and only 9.2% of them knew the side effects of their children's medications.By using a knowledge score, 69 of these parents (57.5%) displayed good knowledge Being an urban residents, younger in age and better educated all have a positive contribution to the amount of knowledge Conclusion: As CHD, being one of the commonest congenital problems affecting children and their parents. The knowledge of the parents should be assessed and measures should be implemented to improve the knowledge of the parents, empowerment of the parents will improve the well being of children with CHD.