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The effects of the selective 5-HT2 receptor antagonist, ritanserin, on the growth hormone (GH) and prolactin (PRL) responses to intravenous L-tryptophan (LTP) were assessed in 8 normal volunteers. Administration of ritanserin (40 mg orally) prior to infusion of LTP (5 g) significantly enhanced the PRL responses but not those of GH. The results are consistent with previous proposals that the endocrine responses to LTP are mediated by 5-HT1 rather than 5-HT2 receptors and also suggest that 5-HT2 receptor antagonists may increase certain 5-HT, mediated responses in the human brain.