Synthesis and Antiviral Activity of 1,2,3-Triazole and 8-Azapurine Derivatives Bearing Acyclic Sugars. -The azides (IV), prepared from the alcohols (Ia) -(Id) and the thiol (Ie) by chloroalkylation and substitution reaction with sodium azide, undergo cyclocondensation with cyanoacetamide (V) in the presence of a base to yield the iminodihydrotriazolecarboxamides (VI). These are cyclized by reaction with ethyl formate (VII) to give the dihydrotriazolopyrimidinones (VIII). Furthermore, azides (IV) are converted into the triazoles (X) and (XII). Some of the triazoles prepared are tested for activity against HSV-1. -(YOKOYAMA, M.; NAKAO, E.; SUJINO, K.; WATANABE, S.; TOGO, H.; Heterocycles 31 (1990) 9, 1669-1685; Dep. Chem., Fac. Sci., Chiba Univ., Yayoi, Chiba 260, Japan; EN)
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