Diabetes is a disorder of excessive urine excretion and chronic hyperglycemia, and glucose participates in diabetic complications such as atherosclerosis, cardiac dysfunction, and nephropathy. Chronic hyperglycemia accelerates activation of the formation of advanced glycation end-products (AGEs), oxidative stress, the polyol pathway, and protein kinase C pathway. These metabolic factors are synergistically correlated with one another; therefore, an effective treatment with wide-spread effects continues to be required.Up to now, there have been many experiments focusing on the treatment of diabetes and its complications with traditional medicines including Chinese prescriptions because of their absence of toxic and/or side-effects. In our previous study, we reported that the Chinese prescriptions Hachimijio-gan and Keishi-bukuryo-gan had potential therapeutic effects against diabetic nephropathy, and had different functions in terms of their effects on metabolic disorders, especially on AGE formation in Hachimi-jio-gan and oxidative stress in Keishi-bukuryo-gan. [1][2][3][4] In addition, we also clarified that administration of dried Rehmanniae Radix (Rehmannia glutinosa LIBOSCH. var. purpurea MAKINO) extract, which is the main constituent of Hachimi-jio-gan, attenuates renal dysfunction in diabetic nephropathy mainly due to its suppression of oxidative stress 5) ; however, for the analysis of this prescription, further characterization of the other constituents is needed. According to the three-dimensional HPLC profile, as previously shown, 2,4) morroniside, loganin, and paeoniflorin were detected as the major compounds in Hachimi-jio-gan. Morroniside and loganin are the components of Corni Fructus (Cornus officinalis SIEB. et ZUCC.) and paeoniflorin is the component of Moutan Cortex (Paeonia suffruticosa ANDREWS) common in Keishi-bukuryogan. Therefore, in order to clarify the source of a particular action of Hachimi-jio-gan, we chose to evaluate the usefulness of one of the crude drugs, Corni Fructus.Corni Fructus has been used as a traditional medicine in Japan and China, and the components of this plant are iridoid total glycoside such as morroniside and loganin and also a few polyphenols such as cornusiin A, B, and C, monomeric and trimeric hydrolysable tannins, and so on.6,7) Recently, it has been reported that Corni Fructus has a plasma glucoselowering action in normal rats, along with anti-neoplastic and anti-microbial effects.8-10) Moreover, Vareed et al. 11) also reported that Corni Fructus has been used for improving liver and kidney functions, and iridoid total glycoside has the effect of preventing the overexpression of transforming growth factor (TGF)-b 1 and matrixes in glomeruli with a diabetic model. 12) However, the mechanisms of Corni Fructus against glucose-associated metabolic disorders in diabetes have yet to be explored. To determine whether Corni Fructus possesses the principal role in Hachimi-jio-gan, which has a strong effect on AGE formation in diabetes and/or diabetic nephropathy, we e...
ABSTRACT--Out of 78 diseased guppies imported from Singapore to Japan, 43 fish were found infected with ciliates.
Many studies have explored the association between health literacy and health-care utilization; however, the majority assessed functional health literacy in terms of basic skills. Japan's health-care and medical examination system in workplaces is different from that of other major countries. This study examined the relationship of health literacy with health-care use (emergency visit, hospitalization, dental checkup, and health checkup or cancer screening); it focused on differences by occupation and health-care service utilization among general Japanese using the communicative and critical health literacy scale. We conducted a cross-sectional observational study of 1002 Japanese residents. Through a questionnaire, we investigated socioeconomic status, health status, health-care use, and health literacy. Among all participants and non-workers, logistic regression analyses revealed that health literacy was significantly associated with health checkup or cancer screening after adjusting for sex, age, marital status, education, and having a disease or disorder (adjusted odds ratio [OR] = 1.431, 95% confidence interval [CI], 1.131–1.810; adjusted OR = 1.614, 95% CI, 1.114–2.339, respectively). Among workers, we observed no significant association between health literacy and health-care utilization. These results indicate that health literacy is closely related to use of preventive health-care. Japan's health-care system in workplaces may promote use of preventive health-care services regardless of health literacy, whereas improving health literacy may be more critical among non-workers.
Japan has the highest number of cases of infertility treatment in the world. Studies have indicated that women undergoing infertility treatment feel stigmatized and suffer from psychological symptoms such as anxiety and depression. However, in Japan, few studies have quantitatively examined the association between the stigma of infertility and psychological symptoms, and, to our knowledge, no study has examined its association using a scale with tested reliability and validity. This study aims to quantitatively examine the relationship between infertility stigma and anxiety, depression, and psychological distress among women undergoing infertility treatment, using a scale that has been validated for reliability and validity. The cross-sectional study was conducted in December 2021 through a web-based survey of 254 participants undergoing infertility treatment. A multiple regression analysis was performed to examine the relationship between stigma and anxiety, depression, and psychological distress. Stigma was a statistically significant predictor of anxiety, depression, and psychological distress (standardized β = 0.58, p < 0.001; β = 0.50, p < 0.001; β = 0.62, p < 0.001, respectively) after controlling for sociodemographic and infertility characteristics. Future studies should examine the causal relationship between stigma and anxiety, depression, and psychological distress and how to intervene to reduce stigma among women undergoing infertility treatment.
Processing fluency (the inferred subjective ease with which people process information) has been a topic of increasing research attention in the field of psychology over the past decade. We examined the effect of improving written materials in terms of processing fluency with regard to encouragement for obtaining breast and cervical cancer screening. We randomly assigned 670 women to intervention or control conditions; the 215 who mailed back distributed questionnaires were the study participants. A standard leaflet for cancer screening was mailed to the control group, while the materials mailed to the intervention group were improved in terms of perceptual fluency (e.g., legibility), linguistic fluency (e.g., readability), retrieval fluency (e.g., reducing amount of information) and imagery fluency (having recipients imagine future behavior and events). The screening rate of the intervention group was significantly higher than that of the control group (29.4% vs. 14.2%, χ = 7.275, df = 1, p = .007, φ = .184). Improving the processing fluency of written materials may be useful for encouraging individuals to obtain breast and cervical cancer screening.
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