We present here findings of a strong positive correlation between reduced daptomycin susceptibility and vancomycin resistance in vancomycin-intermediate Staphylococcus aureus (VISA). This correlation is related to cell wall thickening, suggesting that, similar to the case with vancomycin resistance in VISA, the physical barrier of a thickened cell wall may contribute to daptomycin resistance in S. aureus.

The system formed by a trumpet player and his/her instrument can be seen as a non-linear dynamical system, and modeled by physical equations. Numerical tools can then be used to study these models and clarify the influence of the model parameters. The acoustic input impedance, for instance, is strongly dependent on the geometry of the air column and is therefore of primary interest for a musical instrument maker. In this study, a method of continuation of periodic solutions based on the combination of the Harmonic Balance Method (HBM) and the Asymptotic Numerical Method (ANM), is applied to a physical model of brass instruments. It allows the study of the evolution of the system where one parameter of the model (static mouth pressure) varies. This method is used to compare different B trumpets on the basis of two descriptors (hysteresis behavior and dynamic range) computed from the continuation outputs. Resultsshow that this methodology enables to differentiate instruments in the space of the calculated descriptors.Calculations for different values of the lip parameters are also performed to confirm that the obtained categorization is independent of variations of lip parameters.

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