AIPmut pituitary adenomas have clinical features that may negatively impact treatment efficacy. Predisposition for aggressive disease in young patients, often in a familial setting, suggests that earlier diagnosis of AIPmut pituitary adenomas may have clinical utility.

PC associates with severe primary hyperparathyroidism and must be suspected if calcium ≥1.77 mmol/l. The prevalence of CDC73 germline mutations in PC and APA in Finland is 6%. PC has distinct histopathological characteristics and its incidence has increased over the past decades.

Calving and calf production were studied in an experimental reindeer (Rarigifcr tarandus L) herd in Inari, Kaamanen (69°10'N) in northern Finland. Most of the calving took place between May 10 and 29; 50% of the calves were born up to 22.5. and 90% up to 29.5. The percentage of calves (calves/hinds proceeding year) was on average 79.2%. The newborn sex ratio was 1:1. There was a large range (1.8 to 8.5 kg) in the birth-weight of newborn calves; male calves weighed about 0.3 kg more than female. The total loss of calves during summer and autumn was about 34.5% (range 6.3 to 100.0%). During the calving period 111 calves (12.2%) died. They were usually younger than one day, and on average weighed 1.3 kg less at birth than calves who lived until autumn. The hinds of calves dying very early were usually young and calving for the first time. The autumn-weight of hinds correlated significantly (r = 0.49) with the birth-weight of their calves. Over-5-year-old and over 80 kg hinds bore the heaviest calves (mean weight 6.3 kg) and the survival of these calves was very good. The first hinds to calve in the spring (calving up to 22.5.) are 5-year-old and older, which arc also the heaviest and produce the most vital calves.

Objective: The existence of genotype-phenotype correlation in multiple endocrine neoplasia type 1 (MEN1) is controversial. Two founder mutations of the MEN1 gene in Northern Finland gave us an opportunity to compare clinical features among heterozygotes of different mutations. Results: Founder mutations 1466del12 and 1657insC were found in 39 and 29 individuals, and D418N, G156R and R527X mutations in 9, 3 and 2 individuals respectively. Except for pituitary adenoma and nonfunctional pancreatic tumour (NFPT), age was a risk factor for all the disease manifestations. For NFPT, frameshift/nonsense mutations (1657insC, R527X) gave an odds ratio (OR) of 3.26 (95% confidence intervals (CI), 1.27-8.33; PZ0.014) compared with in-frame/missense mutations (1466del12, D418N, G156R); including the founder mutation carriers (nZ68) only, the 1657insC mutation gave an OR of 3.56 (CI, 1.29-9.83; PZ0.015). For gastrinoma, in-frame/missense mutations predicted the risk with an OR of 6.77 (CI, 1.31-35.0; PZ0.022), and in the founder mutations group the 1466del12 mutation gave an OR of 15.09 (CI, 1.73-131.9, PZ0.014).