Background: The use of topical mitomycin C in ophthalmology is increasing in all sub-specialties, but the risk-benefit ratio should be considered, taking into account its complications. The dose and duration of application of MMC depend on the surgery in which it is used but is still controversial. Objective: To evaluate the changes in the normal histology of the anterior surface structures of the rabbit eye "conjunctiva, cornea and sclera" after subconjunctival injection of different doses of Mitomycin C (0.1, 0.2 and 0.4 mg/ ml) after different periods (1, 7 and 14 days). Material and Methods: A comparative prospective case-control animal study included eighteen eyes of eighteen healthy New Zealand rabbits conducted at the Faculty of Medicine, Al-Azhar Universityfrom April 2019 to October 2019. Results: Group B and C rabbits' eyes clinically throughout the study revealed significant findings in the form of severe congestion, severe chemosis, lid edema, and lacerationswhile group A showed non-significant clinical findings. Histopathological results showed a significant decrease of the conjunctival goblet cells and scleral elastic tissues with MMC administration at different doses even the low dosefrom the 1 st to the 3 rd sacrifice in the dose and time-dependent manner. Scleral thickness showed a significant decrease after 2 weeks of MMC administration.Corneal thickness showed a non-significant decrease within different sacrifices. Conclusion: Preoperative subconjunctival injection of MMC by 0.1 mg/ml concentration one day before, is mainly do not affects the cornea and have the least effects on the conjunctiva and the sclera.
Background:The symptoms of patients with vitreous floaters are frequently underestimated, leading to no intervention. The majority of patients who have floaters receive conservative therapy that includes patient education and reassurance. On the other hand, more severe instances can necessitate pars plana vitrectomy or YAG laser vitreolysis. The potential for conducting vitreolysis using an Nd: YAG laser has arisen as an alternate therapy to avoid the complications of vitrectomy. Aim of The Work:To evaluate the safety and effectiveness profile of YAG laser vitreolysis as a modality of therapy for symptomatic vitreous floaters. Patients and Methods: A prospective study has been done on 50 eyes of 50 patients who had full posterior vitreous detachment and persistent vitreous floaters. The Ultra Q ReflexTM (Ellex Medical Lasers, Adelaide, Australia) was used to perform laser vitreolysis on patients. Follow-up was done for 6 months. Patient satisfaction and complications were recorded. Results: 6% of patients experienced treatment failure, compared to 14% of patients who reported complete success, 46% who reported significant success, and 34% who reported partial success. No complications were recorded in postoperative 6 months follow up period. Conclusion: When used on carefully selected patients, YAG laser vitreolysis represents a safe and efficient therapy for symptomatic vitreous floaters.
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