Our research aims to identify approaches to promoting further education resources. Staff development is the main indicator of employee productivity and a productive "motivation factor" of increasing work initiative, strengthening the personnel behind the enterprise. Modern production places high demands on working personnel and the system of their training and retraining in the conditions of market relations. In the process of scientific and technological progress, some specialties disappear, others arise. All this creates a need for the latest forms of training, retraining and advanced training of employees. In this regard, educational institutions are faced with the need to find potential clients who need to meet the need for professional growth. Competition between organizations in the education market has intensified due to the pandemic. All this makes it relevant to use modern technologies in attracting the attention of employers to the opportunities for retraining and advanced training in a particular educational organization.
The research is aimed at identifying approaches to the promotion of educational resources among the youth audience. Modern educational resources are actively trying to attract young people to self-education, at the same time, the coronavirus pandemic has made the issue of participation in volunteer activities urgent among young people. The article presents a comparative analysis of approaches to the positioning of accounts in social networks aimed at attracting the youth audience to self-education and volunteer activities.
Berberine (BB) is an isoquinoline alkaloid, which is obtained from Berberis (Barberry), more often Berberis vulgaris, of the Berberidaceae family. The interest of the scientific community in this molecule was caused by its vast number of pharmacological effects: antitumor, hypolipidemic, anti-inflammatory, antiarrhythmic, antidiabetic, etc. The antitumor effect of BB consists in the inhibition of the cell cycle in the G1 phase, the induction of apoptosis in tumor cells, the effect on mitogen-activated kinases, and the suppression of metastasis. The main reason for the infrequent use of this molecule is its poor solubility and low bioavailability. Thus, the best solution to overcome these problems is intratumoral implantation. During the analysis of scientific publications, it was found that in the process of developing intratumoral implants when creating matrices with various active substances, it is most often preferred to use poloxamers, since the temperature stimulus is the most characteristic and reliable in therapy. Thus, the aim of the study is to develop the composition and technology of an intratumoral thermosensitive implant of berberine bisulfate (BBB). The study used 101.6% BBB substance (Vifitech, Russia). Kolliphor® P188, Kolliphor® P338, Kollisolv® P124 and Soluplus®, polysorbate-80, PEG-1500 (BASF, Germany) were used as solubilizers. N-methylpyrrolidone was also considered as a candidate for dissolution media. Solubilization of BBB was carried out by adding surfactants and their combinations, by the method of solid dispersions, liquid-liquid extraction. BBB showed very low solubility in N-methylpyrrolidone. The final composition contained Kolliphor® P 407 (15.0%), Kolliphor® P 188 (2.0%), Kollisolv® P124 (2.0%), BBB (1.3%) with a phase transition rate of 2 minutes and phase transition temperature 37-38℃. For the obtained optimal composition, the “Dissolution” test was carried out using a dialysis bag, in a phosphate buffer solution pH 6.8, at a constant temperature of 37℃. Sampling was carried out after 1 hour, 2 hours, 3 hours, 5 hours, 24 hours and 96 hours. The concentration of the substance was determined using spectrophotometry. As a result of the studies carried out, the most suitable composition for an intratumoral implant was created, and the necessary tests were carried out. It can also be concluded that the use of poloxamers is effective in improving the dissolution of BBB. Further research is required.
In modern society, the problem of value orientation of young people to a healthy lifestyle is discussed. Today, the importance of a healthy lifestyle is recognized as a factor of the national security of the state. Introduction to a healthy lifestyle is possible through sports. Often young people, realizing the need to lead a healthy lifestyle, refuse to participate in sports life for fear of failure, lack of the necessary physical ability. Therefore, the popularization of shooting sports, in our opinion, should be aimed at involving young people who may not have succeeded in other sports. The attractiveness of shooting sports is also evident in the fact that there are no strict age limits. It is necessary to analyze the existing approaches to the popularization of shooting sports by the Shooting Sports Federation of Russia (SSR) to identify ways to increase interest in these sports among young people.
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