Baseline PET/CT findings may lead to treatment modification in <15% of patients with HL without a significant impact on outcome. Certain PET/CT parameters have potent prognostic significance.
Aim:
The malignant psoas syndrome (MPS) is a rare and complex cancer-related clinical entity, with a significant impact on cancer patients' quality of life. The literature describing malignant infiltration of the psoas muscle as well as its management is limited. The primary endpoint of the study was the assessment of pain relief in symptomatic terminal-stage MPS patients.
Materials and Methods:
Patients underwent hypofractionated (two- or three-dimensional conformal) radiotherapy as palliative treatment. A dose of 42.5 Gy in 17 daily fractions (2.5 Gy/fraction) was prescribed. Pain response was measured before 3 and 6 months after radiation delivery.
Results:
Between May 1992 and April 2019, eight patients were treated. The median age was 75 years (range: 59–87 years). All patients had distant metastatic disease at the time of treatment. We found a significant pain relief (median duration of response of 105 days) and an improvement in health-related quality of life.
Conclusions:
Radiotherapy had a favorable outcome and can be considered an effective analgesic treatment in case of painful MPS.
Radiation therapy (RT) is an essential component in the therapeutic treatment of patients with localized prostate cancer (LPCa). Besides its local effects, ionizing radiation has been linked to mechanisms leading to systemic immune activation. The present study explored the effect of RT on the T-cell receptor variable β (TCR Vβ) chain repertoire of peripheral blood T cells in patients with LPCa. High-throughput TCR Vβ sequencing was performed on 20 blood samples collected from patients with LPCa at baseline and 3 months post-RT. The diversity index was altered, as were TCR Vβ clonal evenness and convergence before and post-RT; however, these findings were not significant. Notably, marked changes in the frequencies among the top 10 TCR Vβ clonotypes were detected and some patients developed new clonotypes of high abundance. These data provided initial evidence that RT in patients with LPCa may induce systemic immune changes, which could be exploited by future therapies for improved clinical results.
Introduction:
Coexistance of pancreatic carcinoma and Leriche syndrome is an extremely
rare pathological condition. Leriche syndrome is defined as occlusion of the distal aorta at
the bifurcation into the common iliac arteries.
Case Report:
We report the case of a 57-year old male patient with a locally advanced pancreatic
tumor that during chemotherapy presented Leriche syndrome. Four months after the diagnosis and
although the initial staging by MRI had only revealed a few atheromatic lesions of the abdominal
aorta, the patient complained about claudication of the legs and hypoesthesia. Angiography with
multi-detector computed tomography (MDCTA) was performed using aortography protocol and
three-dimensional reconstruction of the images followed, deCmonstrating the relationship between
pancreatic carcinoma and Leriche syndrome.
:
Review of the literature revealed that acute abdominal thrombosis is rare in cancer
patients. To our knowledge, complete occlusion of the aorta in a patient with pancreatic cancer has
not been reported yet.
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