The clinical value of measuring fractional exhaled nitric oxide (FeNO) in asthma is not clear. We aimed to assess whether FeNO can reliably predict clinical outcomes in asthma treated with inhaled corticosteroids (ICS). We also evaluated whether its predictive role is influenced by different inflammatory phenotypes of asthma.We conducted a systematic review focusing on five clinically relevant questions. Two authors independently screened search results, extracted data and assessed quality of the included studies. Data were synthesised by qualitative methods.12 prospective studies were included, answering partly three of the five questions. In steroid-naïve asthma, a high FeNO level probably predicts good response to ICS. In ICS-treated asthmatics, a low FeNO level probably predicts low risk of exacerbation, and the patient is unlikely to benefit from increasing ICS dose. There were scarce data to conclude whether FeNO predicts exacerbations when ICS treatment is stopped in well-controlled asthma. Only one study reported results separately in different asthma phenotypes.The current evidence on the predictive value of FeNO and its role in the management of asthma is incomplete. Future studies should focus on clinically meaningful questions and probably target only eosinophilic phenotypes where FeNO is best associated with the activity of airway inflammation.
Aim This study aimed to describe family caregivers of older people's experiences of participatory art interventions, including music, dance and visual arts. Design A descriptive qualitative study. Methods Thematic interviews were conducted with 12 family caregivers. Qualitative data were analysed with thematic analysis. Results The results illustrated the meaning of art groups, which included a shared feeling of togetherness, empowering and activating peer support and a sense of communality. Art groups also represented a hobby, enhancing caregivers' social and mental well‐being. The art groups could be described as an art‐driven, participatory shared experience. Participatory arts are noteworthy contributors to the well‐being of family caregivers and care recipients, especially from peer support and communality. Further research is needed to find out about participants' preferred art‐based activities and their impact on their well‐being. No patient or public contribution because of inflexibility in the timing of engagement.
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