In this study, we analyzed the putative functions of stabilin-1 in blood monocytes. Microarray analysis revealed downregulation of several proinflammatory genes in the stabilin-1high monocytes when compared with stabilin-1low monocytes. When cocultured with stabilin-1high monocytes, IFN-γ synthesis by T cells was diminished in Ag-recall assays. Knockdown of stabilin-1 in monocytes increased the synthesis of several proinflammatory molecules, including TNF-α, and supported high IFN-γ and low IL-4 and IL-5 production by T cells in Ag-specific stimulation assays. Anti–stabilin-1 Ab treatment also led to increased IFN-γ synthesis in the recall assays. In clinical settings, the expression of stabilin-1 was diminished on blood monocytes and tissue macrophages under proinflammatory conditions. These data define stabilin-1 as a new immunosuppressive molecule and suggest that stabilin-1high monocytes may dampen proinflammatory reactions in vivo.
Background Considering the burden of preeclampsia (PE), it is important to understand better the underlying risk factors involved in its etiology. In this nationwide study, we studied the association of background factors with PE with an emphasis on socioeconomic factors, reproductive factors and health history enclosing the parents of pregnant women. Methods In the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) cohort participants filled in a questionnaire on background information including data on socioeconomic factors, health history and reproductive factors. The questionnaire data was available from 708 women with PE and 724 control women. Two different control groups, healthy controls with uncomplicated pregnancies (n=498) and all controls (n=724, including controls with uncomplicated pregnancies and pregnancy complications other than PE), were established. Background information among PE women and the two different control groups were compared. Results PE women had similar socioeconomic status and more often non-communicable diseases including type I diabetes, chronic hypertension and hyperlipidemia than the two control groups (p<0.05 for all). Depression was more common among PE women (11.4%) than among all controls (7.6%) (p=0.019). Subfertility (estimated by time to pregnancy) was more common among PE women (p=0.013 for healthy controls, p=0.019 for all controls). PE women had earlier menarche (p=0.001 for healthy controls, p=0.022 for all controls). Hypertension was more common in both parents of PE women (p<0.001), stroke in fathers (PE women 6.2 %, healthy controls 3.2 % (p=0.020) and all controls 3.5 % (p=0.022)) and diabetes in mothers (PE women 7.5 %, healthy controls 3.1 % (p=0.001) and all controls 4.3 % (p=0.012)). Mental disorders including depression were more common in mothers of PE women compared to controls (PE women 7.2 %, healthy controls 3.7 % (p=0.013) and all controls 3.9 % (p=0.007)). Conclusions In this Finnish nationwide FINNPEC cohort, PE women had similar socioeconomic status, more non-communicable diseases and depression, earlier menarche, more subfertility and more parental non-communicable diseases compared to controls. As a novel finding we found more mental disorders including depression in mothers of PE women.
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