A new, conformationally mobile, ether-amide, calcium ionophore, l(S^?),2(S^?),4(R,S)-4-Methyll,2-bis((jV,jV-dipropylcarbamyl)methoxy)cyclohexane, is described. The changes in the conformation of the ionophore were monitored by *1 2H and 13C NMR spectroscopy at room temperature and at low temperature (-90 °C). Examination of conformational effects on NMR spectra allowed a direct determination of 2:1 ionophore-to-cation stoichiometry and facilitated the measurement of the association constant. Conformational monitoring of the difference in complexing ability at room temperature and at -90 0C demonstrated that complexation was more pronounced at room temperature. Less effective complexation was demonstrated for magnesium and potassium ions.(2) MARC Graduate Fellow.
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