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A one-step procedure is described for the preparation of l-substituted-4-carbethoxy-2,3-dioxopyrrolidines from ethyl acrylate, a primary aliphatic amine, and ethyl oxalate as starting materials. Three of the products so obtained have been acetylated to yield 3-acetoxy-4-carbethoxy-2-oxo-3-pyrrolines, and seven have been hydrolyzed and decarboxylated to yield l-substituted-2,3-dioxopyrrolidines. Among the latter substances four have been reduced to 3-hydroxy-2-oxopyrrolidines and two further reduced to 3-hydroxypyrrolidines. All of these conversions can be achieved in fair to good yield and may be considered of preparative value.The l-substituted-2,3-dioxopyrrolidines are readily converted into a variety of derivatives by reaction with carbonyl reagents. They also undergo self-condensations of the aldol type with great facility to yield products which contain the 3,3 '-bipyrrolidine system.Recent investigations in this laboratory have led to the development of a new and convenient method of synthesis for 4-carboalkoxy-2,3-dioxopyrrolidines (I) from readily available starting materials. The method is based upon the condensation of alkyl HO-G=C-C02C2H6 !

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Diazouracil (DZU) was shown to increase the mean cell volume of several bacterial species. The filaments which it induced with Escherichia coli B and Lactobacillus casei were examined in section by electron microscopy. In addition to the inhibition of division of E. coli by DZU, its effects were studied on mass increase, viability, and deoxyribonucleic acid, ribonucleic acid, and protein synthesis. The dependence of cell age on the division-inhibitory effect of DZU was examined in synchronous cultures. The division-inhibitory effect was not reversed by pantoyllactone, an antagonist of ultraviolet filamentation, or by l -tyrosine, which had been reported to antagonize DZU activity.