that was presented by the workers at the Western Reserve University that it did not seem necessary to present that today. I have called attention to evidence published in papers lately that the explanation brought forth by those workers does not explain the results, that the amount of epinephrin set free is more than ten times the constant secretion of the suprarenal glands, and, furthermore, they used quantitative amounts, and an unknown amount was lost in preparing it for quantitation. Another paper in press tells of experiments which were performed on animals in which the only abdom¬ inal structures connected with the inferior vena cava were the suprarenal glands. When an afferent nerve was stimu¬ lated, the denervated heart showed characteristic effects due to these circumstances. If a clamp is placed above the suprarenal veins, the heart no longer increases its rate. When the clamp is removed, the heart promptly increases its rate. And, again, on stimulation the heart resumes its effect. If there is any other way of accounting for this than increased secretion of the suprarenal medulla and asphyxiai stimulation, I would be pleased to have some one give me the explanation. So far as Dr. Levy's experiments are concerned, I wrote him about his control. He said he had five controls, animals whose thyroid had been removed previous to the experiment, and neither stimulation of the cervial sympathetic by electricity nor stimulation by large doses of epinephrin had any of the effects under these cir¬ cumstances which they had when the thyroid is in the body.Dr. J. C. Aub, Boston : As to the metabolism in Addison's disease, I was careful to avoid going into the subject. In the first place, I do not think Addison's disease shows an abnormal metabolism; in the second place, the thyroid may well maintain a normal metabolism although the suprarenal may be disturbed. I have been able to find four cases recorded in the literature. These cases, however, have shown a lowered metabolism. I do not think that proves the
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