A high
pressure vessel equipped with continuous magnetic stirring
has been interfaced directly online with supercritical fluid chromatography
(SFC). The interface consists of an oven housing a recirculation pump
that maintains a constant flow of supercritical fluid solution from
the vessel through a sample injection valve for online SFC analysis.
The method involves increasing the vessel pressure in controlled steps
to produce a series of progressively more saturated supercritical
fluid carbon dioxide solutions for online SFC solubility measurements.
The integrated static solubility system provides a convenient means
to ensure equilibrium is established prior to performing online SFC
solubility measurements and also facilitates a self-validation accuracy
check procedure. For nifedipine, solubility data was obtained at 333.15
and 353.15 K through the pressure range from 12.5 to 27.5 MPa using
2.5 MPa steps. For quinine, solubility data was obtained at 323.15
and 343.15 K through the pressure range from 12.5 to 27.5 MPa using
3 MPa steps. All sets of experimental solubility data for each compound
were correlated using the Mendéz-Santiago and Teja model.
The solubilities
of benzoin and 3,3′,4,4′-benzophenonetetracarboxylic
dianhydride in supercritical fluid carbon dioxide have been measured
using static supercritical fluid solubility apparatus directly interfaced
to supercritical fluid chromatography (SFC). The method involves increasing
the pressure of supercritical fluid carbon dioxide in controlled steps
to produce a series of saturated sample solutions that are sequentially
analyzed by online SFC. The system requires minimal manual sample
manipulation stages and facilitates a self-validation check procedure.
Solubility data for benzoin was determined at 308 and 318 K through
the pressure range of 12–24 MPa using 2 MPa steps. Solubility
data for 3,3′,4,4′-benzophenonetetracarboxylic dianhydride
was determined at 328 and 343 K through the pressure range 15–27.5
MPa using 2.5 MPa steps. The Mendéz-Santiago and Teja model
has been successfully applied to correlate all sets of experimental
solubility data.
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